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World J Psychiatry. Jun 19, 2022; 12(6): 779-786
Published online Jun 19, 2022. doi: 10.5498/wjp.v12.i6.779
Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective
Shu Wang, Yu-Guang Guan, Yan-Hua Zhu, Min-Zhong Wang
Shu Wang, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Yu-Guang Guan, Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China
Yu-Guang Guan, Beijing Key Laboratory of Epilepsy, Center of Epilepsy, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100093, China
Yan-Hua Zhu, Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Min-Zhong Wang, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China
Author contributions: Wang S performed the majority of the writing; Guan YG coordinated the writing of the paper; Zhu YH and Wang MZ designed the outline and coordinated the writing of the paper; Zhu YH and Wang MZ contributed equally to this work as co-corresponding authors.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min-Zhong Wang, MBBS, MD, PhD, Associate Professor, Deputy Director, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Jinan 250021, Shandong Province, China. wmzwlq@163.com
Received: January 6, 2022
Peer-review started: January 6, 2022
First decision: March 13, 2022
Revised: April 12, 2022
Accepted: May 14, 2022
Article in press: May 14, 2022
Published online: June 19, 2022
Processing time: 158 Days and 23.7 Hours
Core Tip

Core Tip: Limited reviews in the literature contributed to the high mobility group box 1 (HMGB1) in depression. This review provides a comprehensive mechanistic and therapeutic perspective on this topic and proposed that the future perspectives of HMGB1 in depression should be understanding the full signaling pathway of HMGB1 in depression, deeply investigating potential HMGB1 related therapeutic targets, and exploring the role of HMGB1 in depression and combined disease.