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World J Psychiatry. May 19, 2022; 12(5): 673-682
Published online May 19, 2022. doi: 10.5498/wjp.v12.i5.673
Dysregulated cortical synaptic plasticity under methyl-CpG binding protein 2 deficiency and its implication in motor impairments
Wei-Jia Zhang, Ling-Ling Shi, Li Zhang
Wei-Jia Zhang, Ling-Ling Shi, Li Zhang, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China
Author contributions: Zhang WJ and Zhang L prepared the literature reviews and drafted the manuscript with input by Shi LL; Shi LL and Zhang L revised the manuscript and approved it.
Supported by the National Natural Science Foundation of China, No. 81771222; the Guangdong Province Basic and Applied Basic Research Fund Project, No. 2019A1515011316; and the Guangzhou Science and Technology Plan Project, No. 202007030011.
Conflict-of-interest statement: All authors declare no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Zhang, PhD, Associate Professor, GHM Institute of CNS Regeneration, Jinan University, No. 601 Huangpu Avenue West, Guangzhou 510632, Guangdong Province, China. zhangli@jnu.edu.cn
Received: April 15, 2021
Peer-review started: April 15, 2021
First decision: June 17, 2021
Revised: July 16, 2021
Accepted: April 1, 2022
Article in press: April 1, 2022
Published online: May 19, 2022
Processing time: 397 Days and 18.8 Hours
Core Tip

Core Tip: In this mini-review, Zhang WJ summarized current findings for the synaptic plasticity in the cortex and related motor learning functions under the scenario of Rett syndrome. The discussion of neuropathological mechanisms can help us to better understand the disease progression and more importantly to develop more effective measures to counteract motor deficits.