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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Mar 19, 2022; 12(3): 450-469
Published online Mar 19, 2022. doi: 10.5498/wjp.v12.i3.450
Published online Mar 19, 2022. doi: 10.5498/wjp.v12.i3.450
Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia
Lisa Edelkraut, Diana López-Barroso, María José Torres-Prioris, Guadalupe Dávila, Department of Psychobiology and Methodology of Behavioral Science, Faculty of Psychology and Speech Therapy, University of Malaga, Malaga 29071, Spain
Lisa Edelkraut, Diana López-Barroso, María José Torres-Prioris, Jessica Aloisi, Marcelo L Berthier, Guadalupe Dávila, Cognitive Neurology and Aphasia Unit, Centro de Investigaciones Médico-Sanitarias, University of Malaga, Malaga 29010, Spain
Lisa Edelkraut, Diana López-Barroso, María José Torres-Prioris, Marcelo L Berthier, Guadalupe Dávila, Instituto de Investigación Biomédica de Málaga, University of Malaga, Malaga 29010, Spain
Sergio E Starkstein, School of Psychiatry and Neurosciences, The University of Western Australia, Perth 6009, Australia
Ricardo E Jorge, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Dávila G, Berthier ML, Edelkraut L, López-Barroso D and Torres-Prioris MJ were involved in the acquisition of the original data; Dávila G, Berthier ML and Edelkraut L conceived and designed the manuscript; Dávila G, Berthier ML and Edelkraut L reviewed the literature; López-Barroso D, Torres-Prioris MJ, Aloisi J, Starkstein SE and Jorge RE analyzed the language and neuropsychiatric original data; López-Barroso D and Torres-Prioris MJ analyzed neuroimaging data and created the figure; Dávila G, Berthier ML, López-Barroso D, Torres-Prioris MJ, Starkstein SE, Jorge RE and Edelkraut L wrote the manuscript; all authors gave final approval of the current version of the article to be published.
Supported by Ministerio de Economía , Industria y Competitividad, Instituto de Salud Carlos III, Madrid, Spain, No. PI16/01514.
Institutional review board statement: The study was approved by the Ethical Research of Drugs Committee Provincial of Malaga and the Spanish Drug and Healthcare Products Agency, Spain (Approval No. FIM-DON-2017-01).
Informed consent statement: All study participants, and their legal guardians, provided informed written consent prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guadalupe Dávila, PhD, Associate Professor, Department of Psychobiology and Methodology of Behavioral Science, Faculty of Psychology and Speech Therapy, University of Malaga, Campus de Teatinos, s/n, Malaga 29071, Spain.
Received: June 30, 2021
Peer-review started: June 30, 2021
First decision: July 28, 2021
Revised: August 13, 2021
Accepted: February 10, 2022
Article in press: February 10, 2022
Published online: March 19, 2022
Processing time: 260 Days and 19.5 Hours
Peer-review started: June 30, 2021
First decision: July 28, 2021
Revised: August 13, 2021
Accepted: February 10, 2022
Article in press: February 10, 2022
Published online: March 19, 2022
Processing time: 260 Days and 19.5 Hours
Core Tip
Core Tip: The literature on neuropsychiatric disorders in persons with aphasia (PWA) is limited, given that this population is usually excluded from neuropsychiatric evaluations. This article provides a state-of-art analysis on the prevalence, nature, pathophysiology, assessment, and treatment of neuropsychiatric symptoms (NPS) in PWA. We also report findings from a proof-of-concept observational study that included 20 PWA after chronic left hemisphere lesions which identified a spectrum of NPS, primarily depression, irritability, agitation, anxiety, and apathy.