©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatry. Mar 19, 2022; 12(3): 379-392
Published online Mar 19, 2022. doi: 10.5498/wjp.v12.i3.379
Published online Mar 19, 2022. doi: 10.5498/wjp.v12.i3.379
Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders
Xiao-Pei Zhao, Hui Li, Ru-Ping Dai, Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Zhao XP collected the data and wrote the paper; Li H and Dai RP collected the data and supervised the writing of the paper.
Supported by National Natural Science Foundation of China , No. 82071347 and No. 81771354 (to Dai RP) .
Conflict-of-interest statement: The authors declare no conflict of interest.
Corresponding author: Ru-Ping Dai, MD, PhD, Academic Research, Chief Doctor, Director, Doctor, Professor, Department of Anesthesiology, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China.
Received: March 29, 2021
Peer-review started: March 29, 2021
First decision: August 19, 2021
Revised: August 22, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: March 19, 2022
Processing time: 348 Days and 1.7 Hours
Peer-review started: March 29, 2021
First decision: August 19, 2021
Revised: August 22, 2021
Accepted: January 22, 2022
Article in press: January 22, 2022
Published online: March 19, 2022
Processing time: 348 Days and 1.7 Hours
Core Tip
Core Tip: The neuroimmune crosstalk plays a crucial role in the regulation of mood disorders. Recent studies have shown that the brain-derived neurotrophic factor (BDNF) and its precursor pro-BDNF are cardinal regulators in the neuroimmune axis. However, the roles and potential mechanisms of BDNF/pro-BDNF signaling in the neuroimmune crosstalk in the context of mood disorders remain unexplored. In this review, we summarize recent studies on the role of BDNF/TrkB signaling and pro-BDNF/p75NTR signaling in the neuroimmune axis and how they influence the development of mood disorders.