©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Psychiatr. Oct 19, 2020; 10(10): 223-233
Published online Oct 19, 2020. doi: 10.5498/wjp.v10.i10.223
Published online Oct 19, 2020. doi: 10.5498/wjp.v10.i10.223
Mechanisms of repetitive transcranial magnetic stimulation for anti-depression: Evidence from preclinical studies
Di Luan, Ya-Chen Shi, Ling Li, Yu-Jia Cao, Zhi-Jun Zhang, Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Ming-Ge Zhao, Hai-Xia Feng, Department of Nursing, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Zhi-Jun Zhang, Department of Psychology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
Zhi-Jun Zhang, Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang province, China
Author contributions: Luan D and Zhang ZJ developed the framework of the paper; Luan D wrote the first draft; all authors worked in subsequent drafts, confirmed the last version before submission, and approved the final manuscript.
Supported by the National Key R and D Program of China , No. 2016YFC1306700 ; The Key Projects of National Natural Science Foundation of China , No. 81830040 ; Science and Technology Program of Guangdong , China, No. 2018B030334001; and Program of Excellent Talents in Medical Science of Jiangsu Province , China, No. JCRCA2016006.
Conflict-of-interest statement: The authors deny any conflict of interest.
Corresponding author: Zhi-Jun Zhang, MD, PhD, Doctor, Full Professor, Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, No. 87 Dingjiaqiao, Nanjing 210009, Jiangsu Province, China. janemengzhang@vip.163.com
Received: June 16, 2020
Peer-review started: June 16, 2020
First decision: July 30, 2020
Revised: August 11, 2020
Accepted: September 2, 2020
Article in press: September 2, 2020
Published online: October 19, 2020
Processing time: 126 Days and 15.1 Hours
Peer-review started: June 16, 2020
First decision: July 30, 2020
Revised: August 11, 2020
Accepted: September 2, 2020
Article in press: September 2, 2020
Published online: October 19, 2020
Processing time: 126 Days and 15.1 Hours
Core Tip
Core Tip: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder. This paper reviews the anti-depressant mechanisms of rTMS that have been found in preclinical studies in recent years and discusses the shortcomings of TMS in preclinical studies.