Complex posttraumatic stress disorder: The need to consolidate a distinct clinical syndrome or to reevaluate features of psychiatric disorders following interpersonal trauma?

Abstract

Complex posttraumatic stress disorder (Complex PTSD) has been recently proposed as a distinct clinical entity in the WHO International Classification of Diseases, 11^th version, due to be published, two decades after its first initiation. It is described as an enhanced version of the current definition of PTSD, with clinical features of PTSD plus three additional clusters of symptoms namely emotional dysregulation, negative self-cognitions and interpersonal hardship, thus resembling the clinical features commonly encountered in borderline personality disorder (BPD). Complex PTSD is related to complex trauma which is defined by its threatening and entrapping context, generally interpersonal in nature. In this manuscript, we review the current findings related to traumatic events predisposing the above-mentioned disorders as well as the biological correlates surrounding them, along with their clinical features. Furthermore, we suggest that besides the present distinct clinical diagnoses (PTSD; Complex PTSD; BPD), there is a cluster of these comorbid disorders, that follow a continuum of trauma and biological severity on a spectrum of common or similar clinical features and should be treated as such. More studies are needed to confirm or reject this hypothesis, particularly in clinical terms and how they correlate to clinical entities’ biological background, endorsing a shift from the phenomenologically only classification of psychiatric disorders towards a more biologically validated classification.

Keywords: Complex posttraumatic stress disorder; Posttraumatic stress disorder; Borderline personality disorder; Trauma; Complex trauma

Core tip: A cluster of complex posttraumatic stress disorder (PTSD), PTSD and borderline personality disorder that have in common a history of trauma, is proposed, as a clinical and biological continuum of symptom severity, to be classified together under trauma-related disorders instead of just distinct clinical diagnoses. Trauma depending on biological vulnerability and other precipitating risk factors is suggested that it can lead to either what we commonly diagnose as PTSD or to profound and permanent personality changes, with complex PTSD being an intermediate in terms of its clinical presentation and biological findings so far.