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World J Psychiatry. Jul 19, 2025; 15(7): 107130
Published online Jul 19, 2025. doi: 10.5498/wjp.v15.i7.107130
Debating the link between atrial fibrillation and psychiatric diseases through Ca2+/cAMP signaling
Leandro Bueno Bergantin
Leandro Bueno Bergantin, Department of Pharmacology, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil
Author contributions: Bergantin LB designed the research; Bergantin LB performed the research; Bergantin LB analyzed data; Bergantin LB wrote the paper.
Conflict-of-interest statement: The author has no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Leandro Bueno Bergantin, MD, PhD, Professor, Department of Pharmacology, Universidade Federal de São Paulo, Rua Pedro de Toledo, 669 Vila Clementino, São Paulo 04039-032, Brazil. leanbio39@yahoo.com.br
Received: March 16, 2025
Revised: April 25, 2025
Accepted: May 29, 2025
Published online: July 19, 2025
Processing time: 116 Days and 13.1 Hours
Abstract

Atrial fibrillation (AF) is a very common tachyarrhythmia in clinical practice. Several risk factors, such as higher inflammatory marker levels, diabetes mellitus, hypertension, valvular disease, ischemic heart disease, heart failure, and obesity have been proposed to enhance the risk of AF, contributing to higher healthcare system utilization rates and socioeconomic costs. Some interesting studies also investigated the link between AF and psychiatric diseases. This article debates this link between AF and psychiatric diseases from the perspective of Ca2+/cAMP signaling.

Keywords: Ca2+/cAMP signaling; Psychiatric diseases; Atrial fibrillation; Inflammatory diseases; Neurotransmitters

Core Tip: Atrial fibrillation (AF) is recognized as one of the most frequently occurring tachyarrhythmias in clinical practice. This condition has been associated with an elevated risk of cardiovascular complications and increased mortality rates. Various contributing factors, including heightened levels of inflammatory markers, diabetes mellitus, hypertension, valvular disease, ischemic heart conditions, heart failure, and obesity, have been identified as potential influences on AF development. This article debates the link between AF and psychiatric diseases from the perspective of Ca2+/cAMP signaling.