Xiang FY, Li XK. Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue. World J Psychiatry 2025; 15(2): 99299 [DOI: 10.5498/wjp.v15.i2.99299]
Corresponding Author of This Article
Xin-Ke Li, PhD, Associate Professor, Postdoc, College of Medical Informatics, Chongqing Medical University, No. 1 Medical School Road, Chongqing 400016, China. lixinke@cqmu.edu.cn
Research Domain of This Article
Psychology, Multidisciplinary
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Feb 19, 2025; 15(2): 99299 Published online Feb 19, 2025. doi: 10.5498/wjp.v15.i2.99299
Improving the outcome in leukemia patients by controlling subthreshold depression and cancer-related fatigue
Fa-Yang Xiang, Xin-Ke Li
Fa-Yang Xiang, Xin-Ke Li, College of Medical Informatics, Chongqing Medical University, Chongqing 400016, China
Author contributions: Xiang FY designed the overall concept and outline of the manuscript, and wrote the first draft; Li XK wrote and edited the manuscript and reviewed the literature; all authors reviewed and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Ke Li, PhD, Associate Professor, Postdoc, College of Medical Informatics, Chongqing Medical University, No. 1 Medical School Road, Chongqing 400016, China. lixinke@cqmu.edu.cn
Received: July 19, 2024 Revised: November 29, 2024 Accepted: December 13, 2024 Published online: February 19, 2025 Processing time: 179 Days and 4.6 Hours
Abstract
Patients with leukemia often suffer from the combined effects of cancer-related fatigue (CRF) and subthreshold depression, which mutually exacerbate each other in a vicious cycle. In this editorial, we comment on the article by Liu et al, published in the World Journal of Psychiatry. We further elucidate the profound impact of subthreshold depressive symptoms on the experience of CRF and complications in patients with leukemia. This editorial highlights the importance of early identification and treatment of subclinical depression, and advocates for a multidisciplinary and integrated treatment approach that includes social support, psychological interventions, and individualized treatment plans. Future research needs to explore the biological mechanisms underlying the interaction between the two to develop more effective prevention and treatment strategies.
Core Tip: This editorial focuses on the relationship and impact of leukemia, subthreshold depression, and cancer-related fatigue (CRF), and provides insights for subsequent clinical care and individualized interventions for patients with leukemia. In addition, it offers reflections on the direction of research in subthreshold depression and CRF.
