Published online Dec 19, 2025. doi: 10.5498/wjp.v15.i12.112655
Revised: September 23, 2025
Accepted: October 29, 2025
Published online: December 19, 2025
Processing time: 100 Days and 1.1 Hours
Patients who undergo radical cervical cancer surgery often experience sexual dysfunction and psychological distress, which seriously affects their quality of life. This study aimed to evaluate the clinical effectiveness of mindfulness-based stress reduction (MBSR) therapy for psychosexual adaptation in patients after radical cervical cancer surgery.
To systematically evaluate the clinical effectiveness of MBSR therapy on psychosexual adaptation in patients following radical cervical cancer surgery.
A multicenter retrospective study design was used to analyze the clinical data of 280 patients who underwent radical cervical cancer surgery between January 2021 and August 2024 at Lishui Central Hospital, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Hospital of Zhejiang University and Wen
After intervention, patients in the MBSR intervention group showed significant improvement in anxiety and depression levels (anxiety: 5.8 ± 1.2 vs 8.3 ± 1.7, P < 0.001; depression: 6.2 ± 1.4 vs 9.1 ± 1.8, P < 0.001). The proportion of patients with clinically significant anxiety decreased from 69.3% to 21.4% (control group: 67.9%-52.9%, P < 0.001). The intervention group showed significantly better Female Sexual Function Index total scores (23.5 ± 3.6 vs 17.8 ± 3.2, P < 0.001) and scores in all dimensions than the control group, with a significantly lower incidence of sexual dysfunction (42.9% vs 67.9%, P < 0.001). Regarding sexual relationship satisfaction, both patients in the intervention group (78.3 ± 6.5 vs 65.2 ± 7.8, P < 0.001) and their partners (76.9 ± 7.1 vs 63.6 ± 8.3, P < 0.001) showed significantly improved scores. Age-stratified analysis showed that MBSR was most effective in younger patients (≤ 45 years, 46-55 years; P < 0.001), with relatively less benefit in older patients (> 55 years; P = 0.032). Multivariate regression analysis confirmed that MBSR intervention [odds ratios (OR) = 2.86, 95% confidence interval (95%CI): 1.75-4.68, P < 0.001] and partner support (OR = 1.92, 95%CI: 1.28-2.87, P = 0.002) were independent positive predictive factors for improving patients' psychosexual adaptation.
MBSR therapy can effectively improve anxiety and depression in patients after radical cervical cancer surgery and significantly enhance sexual function and sexual relationship satisfaction, with the effects being more pronounced in younger patients. This study demonstrated that MBSR, as an integrative intervention approach, has independent positive effects on psychosexual adaptation in post-operative cervical cancer patients and is worthy of promotion in clinical practice.
Core Tip: This multicenter retrospective study investigated the impact of mindfulness-based stress reduction (MBSR) on psychological sexual adaptation in patients after radical cervical cancer surgery. MBSR significantly improved anxiety, depression, sexual function, and sexual relationship satisfaction compared to standard care. Both patients and their partners reported enhanced intimacy and emotional connections. Younger patients benefited more than older patients. Multivariate analysis confirmed that MBSR and partner support are independent predictors of psychosexual recovery. The findings support MBSR as an effective integrative intervention for improving postoperative quality of life in cervical cancer survivors.