Gu X, Wang XY, Zhang JN. Psychological and social risk factors and mental health interventions in tuberculous meningitis: A research progress. World J Psychiatry 2025; 15(11): 109760 [PMID: 41281502 DOI: 10.5498/wjp.v15.i11.109760]
Corresponding Author of This Article
Jian-Na Zhang, Department of Emergency Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610044, Sichuan Province, China. zhangjianna1983@126.com
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Psychology, Clinical
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Minireviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Nov 19, 2025 (publication date) through Nov 25, 2025
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World Journal of Psychiatry
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2220-3206
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Gu X, Wang XY, Zhang JN. Psychological and social risk factors and mental health interventions in tuberculous meningitis: A research progress. World J Psychiatry 2025; 15(11): 109760 [PMID: 41281502 DOI: 10.5498/wjp.v15.i11.109760]
World J Psychiatry. Nov 19, 2025; 15(11): 109760 Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.109760
Psychological and social risk factors and mental health interventions in tuberculous meningitis: A research progress
Xue Gu, Xiao-Yan Wang, Jian-Na Zhang
Xue Gu, Xiao-Yan Wang, Jian-Na Zhang, Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610044, Sichuan Province, China
Xue Gu, Xiao-Yan Wang, Jian-Na Zhang, Disaster Medical Center, Sichuan University, Chengdu 610044, Sichuan Province, China
Xue Gu, Xiao-Yan Wang, Jian-Na Zhang, Nursing Key Laboratory of Sichuan Province, Chengdu 610044, Sichuan Province, China
Author contributions: Gu X designed and performed the research and wrote the paper; Wang XY designed the research and contributed to the analysis and provided clinical advice; Zhang JN supervised the report.
Conflict-of-interest statement: The author has no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Na Zhang, Department of Emergency Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610044, Sichuan Province, China. zhangjianna1983@126.com
Received: June 13, 2025 Revised: July 21, 2025 Accepted: September 12, 2025 Published online: November 19, 2025 Processing time: 143 Days and 18.7 Hours
Abstract
Tuberculous meningitis (TBM), which accounts for 1%-5% of global tuberculosis cases, is a severe neurological infection with a mortality rate of 30%-50%. Its high fatality and disability rates disproportionately affect low- and middle-income regions (e.g., sub-Saharan Africa and Southeast Asia), threatening the lives of patients and imposing significant psychosocial burdens. Recent studies have highlighted the crucial role of psychosocial factors, including socioeconomic status, disease severity, and social support systems in recovery. However, research gaps persist in developing TBM-specific psychosocial interventions. This narrative review summarizes and organizes the key findings of observational studies, cohort studies, and intervention trials published between 2015 and 2024. Databases including PubMed, Scopus, and Web of Science were searched for terms related to TBM, psychosocial risk factors and mental health interventions. Studies were screened for relevance and quality, focusing on those that examined the psychological and social determinants of mental health outcomes in patients with TBM.
Core Tip: Tuberculous meningitis poses severe psychosocial risks, including depression and anxiety, exacerbated by low socioeconomic status and lack of social support. Effective interventions like cognitive behavioral therapy and community-based programs can improve mental health outcomes, especially in low-income regions. Integrating mental health services with tuberculosis control is crucial for comprehensive care.
