You YT, Guo R. Association between anxiety and depression and sleep quality in benign laryngotracheal stenosis patients and analysis of risk factors. World J Psychiatry 2025; 15(10): 108844 [DOI: 10.5498/wjp.v15.i10.108844]
Corresponding Author of This Article
Rui Guo, Associate Chief Physician, Department of Otolaryngology Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 818 Renmin Road, Changde 415000, Hunan Province, China. guorui860908@163.com
Research Domain of This Article
Psychology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Oct 19, 2025; 15(10): 108844 Published online Oct 19, 2025. doi: 10.5498/wjp.v15.i10.108844
Association between anxiety and depression and sleep quality in benign laryngotracheal stenosis patients and analysis of risk factors
Ya-Ting You, Rui Guo
Ya-Ting You, Rui Guo, Department of Otolaryngology Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), Changde 415000, Hunan Province, China
Author contributions: You YT designed the research and wrote the first manuscript; You YT and Guo R contributed to conceiving the research and analyzing data; You YT and Guo R conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Supported by Science and Technology Innovation Program of Changde City, No. 2024ZD165; and Hunan Provincial Natural Science Foundation of China, No. 2025JJ80419.
Institutional review board statement: This study was approved by the Ethic Committee of the first people’s hospital of Changde city.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We declare that there is no disclosure of any interest relationship.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui Guo, Associate Chief Physician, Department of Otolaryngology Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People’s Hospital of Changde City), No. 818 Renmin Road, Changde 415000, Hunan Province, China. guorui860908@163.com
Received: July 4, 2025 Revised: July 29, 2025 Accepted: August 13, 2025 Published online: October 19, 2025 Processing time: 84 Days and 0.3 Hours
Abstract
BACKGROUND
Benign laryngotracheal stenosis (LTS) is a condition characterized by mucosal inflammation and fibrosis. It is difficult to treat with a high incidence rate. Respiratory distress and voice disorders of varying severity also affect patients’ sleep quality and quality of life.
AIM
To investigate the association between anxiety and depression and sleep quality in patients with benign LTS and identify significant risk factors for sleep disorders.
METHODS
This retrospective cohort study enrolled 127 consecutive patients with benign LTS admitted to The First People’s Hospital of Changde City between January 2021 and January 2024. Comprehensive assessments included demographic collection and Pittsburgh sleep quality index (PSQI), self-rating anxiety scale (SAS), and self-rating depression scale (SDS) scoring. Correlation analyses were conducted to examine relationships between psychological measures and sleep parameters, followed by multivariate logistic regression to determine independent risk factors.
RESULTS
The cohort demonstrated significantly impaired sleep quality (mean PSQI, 7.79 ± 2.47), with 48.0% (n = 61) meeting the criteria for clinically significant sleep disturbance. The scores of all PSQI dimensions, as well as SAS and SDS scores of patients with LTS, significantly exceeded Chinese normative values. Strong positive correlations emerged between PSQI scores and both SAS and SDS measures. Multivariate logistic analysis identified middle age (41-50 years), multiple surgical interventions (≥ 3 procedures), lower socioeconomic status (monthly household income per capita ≤ 5000 RMB), and concurrent anxiety/depression as independent predictors of sleep disturbance.
CONCLUSION
The results demonstrate a high prevalence of sleep disorders and comorbid anxiety or depressive moods among patients with LTS. These psychological factors both correlate with and independently predict sleep impairment. These results underscore the need for integrated and proactive approaches addressing both physical and mental health components in LTS management, focusing on high-risk subgroups stratified based on age, monthly household income per capita, anxiety/depression status, and number of prior surgeries.
Core Tip: Laryngotracheal stenosis (LTS) is a condition characterized by mucosal inflammation and fibrosis. Changes in the diameter of the laryngotracheal airway and length of the narrowed segment can alter airflow, leading to progressive respiratory distress. Currently, domestic and international research on LTS has primarily focused on treatment modalities, with limited studies on the psychological and sleep-related aspects of patients with LTS. This study aimed to investigate the sleep quality of patients with LTS and its influencing factors, providing a theoretical basis for implementing effective intervention measures to improve the sleep quality of patients with LTS.
