Published online Jan 19, 2025. doi: 10.5498/wjp.v15.i1.100880
Revised: October 18, 2024
Accepted: November 21, 2024
Published online: January 19, 2025
Processing time: 103 Days and 1.2 Hours
The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia, especially thyroid hormones.
To study the relationship between triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH) and schizophrenia.
In this study, 100 schizophrenia patients were selected from our hospital between April 2022 and April 2024. Their clinical data were analyzed retrospectively. Based on the Positive and Negative Syndrome Scale (PANSS) score, patients were divided into mild (1-3 points, n = 39), moderate (4 points, n = 45), and severe groups (5-7 points, n = 16). Additionally, 55 healthy individuals served as a control group. Venous blood samples were collected to measure T3, T4, FT3, FT4, TSH, and cortisol concentrations, analyzing their relationship with PANSS scores.
The serum levels of T3, FT3, FT4, TSH and cortisol in the schizophrenia group were lower than those in the control group (P < 0.05). With the increase of the severity of the disease, the concentrations of T3 and T4 decreased, while the con
Thyroid hormone levels are associated with the severity of schizophrenia symptoms, which can provide new solutions for the diagnosis and treatment of schizophrenia.
Core Tip: Previous studies have confirmed that hormone imbalance is closely related to the occurrence and progression of schizophrenia, especially thyroid hormone. However, the relationship between thyroid hormone and schizophrenia symptoms is still unknown at this stage. Based on this, this study conducted a retrospective analyse to explore the correlation between thyroid hormone levels and the severity of schizophrenia.