Ren XH, Wang XX, He LP. Sodium selenite may be not the optimal speciation as an effective therapy for arsenic-induced anxiety-/depression-like behavior. World J Psychiatry 2022; 12(9): 1255-1257 [PMID: 36186509 DOI: 10.5498/wjp.v12.i9.1255]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Psychiatry. Sep 19, 2022; 12(9): 1255-1257 Published online Sep 19, 2022. doi: 10.5498/wjp.v12.i9.1255
Sodium selenite may be not the optimal speciation as an effective therapy for arsenic-induced anxiety-/depression-like behavior
Xiao-Hua Ren, Xiao-Xuan Wang, Lian-Ping He
Xiao-Hua Ren, Xiao-Xuan Wang, Lian-Ping He, School of Medicine, Taizhou University, Taizhou 318000, Zhejiang Province, China
Author contributions: Ren XH and He LP contributed to the conception of research; Ren XH and Wang XX wrote the letter; Wang XX and He LP contributed to the revision of the letter; all authors approved the final manuscript for submission.
Supported byCurriculum Reform Project of Taizhou University in 2021, No. xkg2021087.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: March 3, 2022 Peer-review started: March 3, 2022 First decision: April 18, 2022 Revised: April 20, 2022 Accepted: August 26, 2022 Article in press: August 26, 2022 Published online: September 19, 2022 Processing time: 201 Days and 6.3 Hours
Abstract
Major depressive disorder is a serious and prevalent neuropsychiatric disorder, affecting more than 350 million people worldwide. Here, sodium selenite (SS) was selected as the selenite supplement to improve the behavior in a mouse model of depression induced by As. SS may be not the optimal speciation for selenite supplementation and the source of the SS used in the study was not disclosed. There are many mouse models of depression and anxiety; however, in the current study, a classical mouse model of depression was not used. Thus, several questions still need to be further discussed. Taken together, the results indicate that SS may be not the optimal speciation as an effective therapy for As-induced anxiety-/depression-like behavior.
Core Tip: Sodium selenite (SS) may be not the optimal speciation for selenite supplementation and the source of the SS used in the study was not disclosed. There are many mouse models of depression and anxiety; however, in the current study, a classical mouse model of depression was not used.
