Published online Aug 19, 2022. doi: 10.5498/wjp.v12.i8.1108
Peer-review started: February 23, 2022
First decision: April 18, 2022
Revised: April 19, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 19, 2022
Processing time: 176 Days and 5.3 Hours
Use of newer antipsychotics for substitution of current antipsychotics might be one way awaiting to be clinically verified to address antipsychotic cardiotoxic effects. Alternatively, the combination of existing antipsychotics with cardioprotective agents is also beneficial for patients with mental disorders for avoiding cardiotoxicity to the maximum.
Core Tip: The newer antipsychotics have been reported to have fewer side effects and better performance in efficacy in short-term studies. Still, a dilemma lies between the benefit of ameliorating psychotic symptoms and severe side effects especially life-threatening cardiotoxicity in antipsychotic medications in clinical practice. The combination of antipsychotics with other therapeutic agents providing cardioprotection, such as β-blockers, cannabinoid 1 receptor antagonists, cannabinoid 2 receptor agonists, spliceosome inhibitors, angiotensin-converting enzyme inhibitors, and ω-3 polyunsaturated fatty acids, may represent a promising strategy and sweet pledge.