Biological mechanisms and possible primary prevention of depression

doi:10.5498/wjp.v12.i5.770

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May 19, 2022 (publication date) through Mar 8, 2026

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World Journal of Psychiatry

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2220-3206

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Letter to the Editor

World J Psychiatry. May 19, 2022; 12(5): 770-772
Published online May 19, 2022. doi: 10.5498/wjp.v12.i5.770

Biological mechanisms and possible primary prevention of depression

Chih-Yun Kuo, Ivo Stachiv

Chih-Yun Kuo, Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague 12108, Czech Republic

Ivo Stachiv, Department of Functional Materials, Institute of Physics, Czech Academy of Sciences, Praha 18021, Czech Republic

Author contributions: Both authors have prepared the manuscript, and contributed equally to this work.

Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Corresponding author: Ivo Stachiv, PhD, Academic Fellow, Associate Professor, Department of Functional Materials, Institute of Physics, Czech Academy of Sciences, Na Slovance 2, Praha 18021, Czech Republic. stachiv@fzu.cz

Received: December 7, 2021
Peer-review started: December 7, 2021
First decision: March 13, 2022
Revised: March 15, 2022
Accepted: April 26, 2022
Article in press: April 26, 2022
Published online: May 19, 2022
Processing time: 161 Days and 9.7 Hours

Abstract

Individuals with unipolar depressive disorder (UDD) are having an increased risk of death and development of dementia in later life. It is widely expected that in a near future UDD would be the leading cause of death; therefore, a primary inexpensive prevention of UDD will be of a great importance to the society. Several studies provide evidences supporting the positive effect of Mediterranean diet on a reduced risk for development of depression.

Keywords: Unipolar depressive disorder; Mediterranean diet; Depression; Primary prevention; Dementia

Core Tip: Dietary interventions, especially Mediterranean diet, may help to reduce the risk for development of depression. It is the high levels of various antioxidant compounds, adequate B-group vitamin and folate content which make the Mediterranean diet a possible candidate for an inexpensive primary intervention of depression. However, the long-term clinical trials on the large cohorts are still necessary to understand the relationship between dietary pattern and development of depression or dementia.