Published online Apr 19, 2022. doi: 10.5498/wjp.v12.i4.580
Peer-review started: May 8, 2021
First decision: July 14, 2021
Revised: August 10, 2021
Accepted: March 14, 2022
Article in press: March 14, 2022
Published online: April 19, 2022
Processing time: 339 Days and 17 Hours
Forced normalization (FN) is a unique phenomenon that is often seen in the treatment of epilepsy. FN is characterized by abnormal mental behavior and disordered emotions in epilepsy patients despite a significantly improved electroencephalogram and successful seizure control; the occurrence of FN seriously affects patients’ quality of life. The causes of FN include antiseizure medications (ASMs), epilepsy surgery and vagus nerve stimulation, with ASMs being the most common cause. However, with the timely reduction or discontinuation of ASMs and the use of antipsychotic drugs, the overall prognosis is good. Here, we perform an extensive review of the literature pertaining to FN, including its epidemiology, possible mechanisms, clinical features, treatment and prognosis.
Core Tip: Forced normalization (FN) is often seen in the treatment of epilepsy. FN is characterized by abnormal behavior and disordered emotions in epilepsy patients despite a significantly improved electroencephalogram and successful seizure control; the occurrence of FN seriously affects patients’ quality of life. However, with timely recognition and treatment, the overall prognosis is good.