Morphological changes in Parkinson's disease based on magnetic resonance imaging: A mini-review of subcortical structures segmentation and shape analysis

doi:10.5498/wjp.v12.i12.1356

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World Journal of Psychiatry

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World J Psychiatry. Dec 19, 2022; 12(12): 1356-1366
Published online Dec 19, 2022. doi: 10.5498/wjp.v12.i12.1356

Morphological changes in Parkinson's disease based on magnetic resonance imaging: A mini-review of subcortical structures segmentation and shape analysis

Jin-Huan Deng, Han-Wen Zhang, Xiao-Lei Liu, Hua-Zhen Deng, Fan Lin

Jin-Huan Deng, Han-Wen Zhang, Xiao-Lei Liu, Hua-Zhen Deng, Fan Lin, Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, Shenzhen 518035, Guangdong Province, China

Author contributions: Authors' contributions: Lin F contributed to the conception of the study; Zhang HW, Liu XL, and Deng HZ contributed significantly to analysis and manuscript preparation; Deng JH and Zhang HW performed the data analyses and wrote the manuscript; Zhang HW and Deng JH contributed equally to this study.

Supported by the Guangdong Basic and Applied Basic Research Foundation, No. 2021A1515220131; Youth Exploration Fund of Shenzhen Health Economics Society, No. 202211; and Clinical Research Project of Shenzhen Second People’s Hospital, No. 223375022.

Conflict-of-interest statement: The authors declare that they have no conflicts of interest.

Corresponding author: Fan Lin, MD, Professor, Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People’s Hospital, No. 3002 Sungangxi Road, Shenzhen 518035, Guangdong Province, China. foxetfoxet@gmail.com

Received: August 23, 2022
Peer-review started: August 23, 2022
First decision: October 21, 2022
Revised: November 2, 2022
Accepted: November 21, 2022
Article in press: November 21, 2022
Published online: December 19, 2022
Processing time: 115 Days and 7.6 Hours

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra, resulting in clinical symptoms, including bradykinesia, resting tremor, rigidity, and postural instability. The pathophysiological changes in PD are inextricably linked to the subcortical structures. Shape analysis is a method for quantifying the volume or surface morphology of structures using magnetic resonance imaging. In this review, we discuss the recent advances in morphological analysis techniques for studying the subcortical structures in PD in vivo. This approach includes available pipelines for volume and shape analysis, focusing on the morphological features of volume and surface area.

Keywords: Parkinson's disease; Dopaminergic neurons; Magnetic resonance imaging; Substantia nigra; Morphological

Core Tip: Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra, resulting in clinical symptoms, including bradykinesia, resting tremor, rigidity, and postural instability. The pathophysiological changes in PD are inextricably linked to the subcortical structures. Shape analysis is a method for quantifying the volume or surface morphology of structures using magnetic resonance imaging. In this review, we discuss the recent advances in morphological analysis techniques for studying the subcortical structures in PD in vivo. This approach includes available pipelines for volume and shape analysis, focusing on the morphological features of volume and surface area.