Review
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World J Med Genet. Nov 27, 2014; 4(4): 94-104
Published online Nov 27, 2014. doi: 10.5496/wjmg.v4.i4.94
Role of SOX2 in foregut development in relation to congenital abnormalities
Kim Schilders, Joshua K Ochieng, Cornelis P van de Ven, Cristina Gontan, Dick Tibboel, Robbert J Rottier
Kim Schilders, Joshua K Ochieng, Cornelis P van de Ven, Cristina Gontan, Dick Tibboel, Robbert J Rottier, Departments of Pediatric Surgery of The Erasmus MC-Sophia Children’s Hospital, 3000 CA Rotterdam, The Netherlands
Cristina Gontan, The Department of Reproduction and Development of the Erasmus MC, 3015 CN Rotterdam, The Netherlands
Robbert J Rottier, Cell Biology of the Erasmus MC, 3000 CA Rotterdam, The Netherlands
Author contributions: Schilders K, Ochieng JK, Gontan C and Rottier RJ wrote the first draft of the manuscript; van de Ven CP and Tibboel D added all patient information; Schilders K, Tibboel D and Rottier RJ provided critical input and comments; all authors edited the manuscript.
Correspondence to: Robbert J Rottier, PhD, Departments of Pediatric Surgery of The Erasmus MC-Sophia Children’s Hospital, PO Box 2040, 3000 CA Rotterdam, The Netherlands. r.rottier@erasmusmc.nl
Telephone: +31-10-7044140 Fax: +31-10-7044468
Received: May 28, 2014
Revised: July 14, 2014
Accepted: September 4, 2014
Published online: November 27, 2014
Processing time: 173 Days and 17.4 Hours
Core Tip

Core tip: Foregut abnormalities are complicated congenital diseases which still lack knowledge of the origin. This review highlights foregut development and associated abnormalities, specifically focussing on the transcription factor SOX2.