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World J Exp Med. Jun 20, 2026; 16(2): 118252
Published online Jun 20, 2026. doi: 10.5493/wjem.v16.i2.118252
Published online Jun 20, 2026. doi: 10.5493/wjem.v16.i2.118252
Unveiling the antibiotic resistance pattern in Staphylococcus aureus: A systematic review (2013-2024)
Snehal M Deshmukhe, Chanda R Vyawahare, Manisha M Ratnaparkhi, Nageswari R Gandham, Department of Microbiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre and Dr. D. Y. Patil Vidyapeeth, Pune 411018, Mahārāshtra, India
Poonam V Suryawanshi, Central Research Facility, Dr. D. Y. Patil Medical College, Hospital and Research Centre and Dr. D. Y. Patil Vidyapeeth, Pune 411018, Mahārāshtra, India
Author contributions: Deshmukhe SM contributed to concept and design, drafted systematic review article, literature search; Vyawahare CR edited manuscript, literature search; Suryawanshi PV contributed to statistical analysis, literature search; Ratnaparkhi MM contributed to write manuscript, literature search; Gandham NR contributed to literature search; Deshmukhe SM, Vyawahare CR, Suryawanshi PV, Ratnaparkhi MM, Gandham NR contributed to finalized manuscript; all authors have reviewed and approved the manuscript.
AI contribution statement: Generative AI tools, including Paper pal and ChatGPT-4o, were utilized solely for language, grammar, and stylistic refinement. These tools had no role in the conceptualization, data analysis, interpretation of results, or substantive content development of this manuscript. All intellectual contributions, data analysis, and scientific interpretations remain the sole work of the authors. The final content was critically reviewed and edited to ensure accuracy and originality. The authors take full responsibility for the accuracy, originality, and integrity of the work presented.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Chanda R Vyawahare, MD, Professor, Department of Microbiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre and Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune 411018, Mahārāshtra, India. chandavyawahare@dpu.edu.in
Received: December 28, 2025
Revised: January 19, 2026
Accepted: March 10, 2026
Published online: June 20, 2026
Processing time: 167 Days and 21.6 Hours
Revised: January 19, 2026
Accepted: March 10, 2026
Published online: June 20, 2026
Processing time: 167 Days and 21.6 Hours
Core Tip
Core Tip: Staphylococcus aureus (S. aureus) antibiotic resistance reveals substantial regional heterogeneity across India, with significant variations in resistance rates even within the same geographical regions. This variance reflects variations in healthcare facilities, socioeconomic characteristics, and antibiotic usage behaviours. The results demonstrate the critical need for region-specific antibiotic stewardship programs and standardized, multicenter surveillance to direct efficient treatment and reduce the rising prevalence of multidrug-resistant S. aureus.