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World J Exp Med. Dec 20, 2024; 14(4): 97179
Published online Dec 20, 2024. doi: 10.5493/wjem.v14.i4.97179
Perspectives on the extracellular matrix in inflammatory bowel disease and bowel decellularization protocols
Caroline Bures de Paulo, Maria Angelica Miglino, Patricia Castelucci
Caroline Bures de Paulo, Department of Surgery, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508-270, São Paulo, Brazil
Maria Angelica Miglino, Laboratório de Medicina Regenerativa, Universidade de Marilia, Marilia 00000, São Paulo, Brazil
Patricia Castelucci, Department of Anatomy, University of São Paulo, São Paulo 05508-000, Brazil
Author contributions: de Paulo CB performed the majority of the writing; Miglino MA contributed to the development of the writing; Castelucci P provided contributions and coordinated the writing of this article.
Supported by São Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP, Brazil), No. 2014/25927-2, No. 2018/07862-1, No. 2021/05445-7, and No. 2022/00086-1; the Brazilian National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq, Brazil); and the Brazilian Federal Agency for Support and Evaluation of Graduate Education (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES, Brazil).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Patricia Castelucci, PhD, Associate Professor, Department of Anatomy, University of São Paulo, 2415, Av. Dr Lineu Prestes, São Paulo 05508-000, Brazil. pcastel@usp.br
Received: May 24, 2024
Revised: September 15, 2024
Accepted: October 15, 2024
Published online: December 20, 2024
Processing time: 159 Days and 8.6 Hours
Core Tip

Core Tip: Regenerative medicine provides a promising perspective in the treatment of inflammatory bowel diseases (IBD) by targeting tissue repair. The development of decellularization techniques to produce scaffolds that mimic the native environment of the intestine is crucial to the advances in this field. This article addresses how research focused on the extracellular matrix in IBD tissues and studies ways to improve regenerative therapies that represent fundamental steps towards furthering the efficacy and safety of IBD treatments.