Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus

doi:10.5493/wjem.v14.i4.95960

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World Journal of Experimental Medicine

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Dec 20, 2024; 14(4): 95960
Published online Dec 20, 2024. doi: 10.5493/wjem.v14.i4.95960

Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus

Dhita Prabasari Wibowo, Agustiningsih Agustiningsih, Sri Jayanti, Caecilia H C Sukowati, Korri Elvanita El Khobar

Dhita Prabasari Wibowo, Agustiningsih Agustiningsih, Sri Jayanti, Caecilia H C Sukowati, Korri Elvanita El Khobar, Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10430, Indonesia

Dhita Prabasari Wibowo, Postgraduate School, Faculty of Medicine, Universitas Hasanuddin, Makassar 90245, Indonesia

Caecilia H C Sukowati, Department of Liver Cancer, Fondazione Italiana Fegato ONLUS, Trieste 34149, Italy

Co-corresponding authors: Caecilia H C Sukowati and Korri Elvanita El Khobar.

Author contributions: Wibowo DP, Agustiningsih A, Jayanti S, Sukowati CHC, and El Khobar KE contributed to this paper; Wibowo DP, Sukowati CHC, and El Khobar KE designed the overall concept and outline of the manuscript; Wibowo DP, Agustiningsih A, Jayanti S, Sukowati CHC, and El Khobar KE contributed to the writing, editing, and review of literature.

Supported by Rumah Program 2024 of Research Organization for Health, National Research and Innovation Agency (BRIN) of Indonesia.

Conflict-of-interest statement: Authors declare no conflict-of-interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Korri Elvanita El Khobar, BSc, MPhil, PhD, Researcher, Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Building B.J. Habibie, Jl. M.H. Thamrin No. 8, Jakarta 10430, Indonesia. korr001@brin.go.id

Received: April 23, 2024
Revised: August 16, 2024
Accepted: September 2, 2024
Published online: December 20, 2024
Processing time: 190 Days and 23.3 Hours

Core Tip

Core Tip: Mother-to-child transmission (MTCT) of the hepatitis B virus (HBV) is still a problem in HBV endemic countries. This review explores the newest information and approaches available in literature to overcome MTCT and its challenges, including screening of pregnant women, prenatal intervention, infant immunoprophylaxis, and post-vaccination serological testing.