Wibowo DP, Agustiningsih A, Jayanti S, Sukowati CHC, El Khobar KE. Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus. World J Exp Med 2024; 14(4): 95960 [PMID: 39713069 DOI: 10.5493/wjem.v14.i4.95960]
Corresponding Author of This Article
Korri Elvanita El Khobar, BSc, MPhil, PhD, Researcher, Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Building B.J. Habibie, Jl. M.H. Thamrin No. 8, Jakarta 10430, Indonesia. korr001@brin.go.id
Research Domain of This Article
Virology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Exp Med. Dec 20, 2024; 14(4): 95960 Published online Dec 20, 2024. doi: 10.5493/wjem.v14.i4.95960
Exploring the impact of hepatitis B immunoglobulin and antiviral interventions to reduce vertical transmission of hepatitis B virus
Dhita Prabasari Wibowo, Agustiningsih Agustiningsih, Sri Jayanti, Caecilia H C Sukowati, Korri Elvanita El Khobar
Dhita Prabasari Wibowo, Agustiningsih Agustiningsih, Sri Jayanti, Caecilia H C Sukowati, Korri Elvanita El Khobar, Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Jakarta 10430, Indonesia
Dhita Prabasari Wibowo, Postgraduate School, Faculty of Medicine, Universitas Hasanuddin, Makassar 90245, Indonesia
Caecilia H C Sukowati, Department of Liver Cancer, Fondazione Italiana Fegato ONLUS, Trieste 34149, Italy
Co-corresponding authors: Caecilia H C Sukowati and Korri Elvanita El Khobar.
Author contributions: Wibowo DP, Agustiningsih A, Jayanti S, Sukowati CHC, and El Khobar KE contributed to this paper; Wibowo DP, Sukowati CHC, and El Khobar KE designed the overall concept and outline of the manuscript; Wibowo DP, Agustiningsih A, Jayanti S, Sukowati CHC, and El Khobar KE contributed to the writing, editing, and review of literature.
Supported byRumah Program 2024 of Research Organization for Health, National Research and Innovation Agency (BRIN) of Indonesia.
Conflict-of-interest statement: Authors declare no conflict-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Korri Elvanita El Khobar, BSc, MPhil, PhD, Researcher, Eijkman Research Center for Molecular Biology, Research Organization for Health, National Research and Innovation Agency of Indonesia, Building B.J. Habibie, Jl. M.H. Thamrin No. 8, Jakarta 10430, Indonesia. korr001@brin.go.id
Received: April 23, 2024 Revised: August 16, 2024 Accepted: September 2, 2024 Published online: December 20, 2024 Processing time: 190 Days and 23.3 Hours
Abstract
Hepatitis B virus (HBV) infection is a major public health burden. In HBV endemic regions, high prevalence is also correlated with the infections acquired in infancy through perinatal transmission or early childhood exposure to HBV, the so-called mother-to-child transmission (MTCT). Children who are infected with HBV at a young age are at higher risk of developing chronic HBV infection than those infected as adults, which may lead to worse clinical outcome. To reduce the incidence of HBV MTCT, several interventions for the infants or the mothers, or both, are already carried out. This review explores the newest information and approaches available in literature regarding HBV MTCT prevalence and its challenges, especially in high HBV endemic countries. This covers HBV screening in pregnant women, prenatal intervention, infant immunoprophylaxis, and post-vaccination serological testing for children.
Core Tip: Mother-to-child transmission (MTCT) of the hepatitis B virus (HBV) is still a problem in HBV endemic countries. This review explores the newest information and approaches available in literature to overcome MTCT and its challenges, including screening of pregnant women, prenatal intervention, infant immunoprophylaxis, and post-vaccination serological testing.
