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World J Exp Med. Jun 20, 2024; 14(2): 88867
Published online Jun 20, 2024. doi: 10.5493/wjem.v14.i2.88867
Ovarian function in patients with systemic lupus erythematosus: Pathogenesis, drug application and prospective therapies
Min Xu, Li-Li Tian, Xiao-Liu Li, Cheng Bao, Hai-Wei Zhang, Hong-Wei Chen
Min Xu, Li-Li Tian, Xiao-Liu Li, Hong-Wei Chen, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, Jiangsu Province, China
Cheng Bao, School of Life Science, Nanjing Normal University, Nanjing 210023, Jiangsu Province, China
Cheng Bao, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China
Hai-Wei Zhang, Department of Rheumatology and Immunology, Nanjing Pukou People’s Hospital, Nanjing 211800, Jiangsu Province, China
Hong-Wei Chen, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, China
Author contributions: Xu M, Tian LL, Li XL, and Bao C wrote the manuscript; Zhang HW performed the research; Chen HW designed the review and were responsible for the final proofreading; All authors have read and approve the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82271843; and Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health, No. ZKX20019.
Conflict-of-interest statement: All authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Chen, PhD, Associate Professor, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of School of Medicine, Nanjing University, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. chenhw@nju.edu.cn
Received: October 12, 2023
Revised: February 27, 2024
Accepted: April 9, 2024
Published online: June 20, 2024
Processing time: 251 Days and 3.7 Hours
Core Tip

Core Tip: Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in women of childbearing age. Disorders of the immune system and clinical treatment drugs can affect the ovarian and reproductive functions of female patients. Herein, we summarize the research progress on SLE combined with ovarian dysfunction, hoping to provide a reference for the clinical treatment of patients with SLE for ovarian function and fertility needs.