Xu M, Tian LL, Li XL, Bao C, Zhang HW, Chen HW. Ovarian function in patients with systemic lupus erythematosus: Pathogenesis, drug application and prospective therapies. World J Exp Med 2024; 14(2): 88867 [PMID: 38948422 DOI: 10.5493/wjem.v14.i2.88867]
Corresponding Author of This Article
Hong-Wei Chen, PhD, Associate Professor, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of School of Medicine, Nanjing University, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. chenhw@nju.edu.cn
Research Domain of This Article
Immunology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Min Xu, Li-Li Tian, Xiao-Liu Li, Hong-Wei Chen, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, Jiangsu Province, China
Cheng Bao, School of Life Science, Nanjing Normal University, Nanjing 210023, Jiangsu Province, China
Cheng Bao, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Nanjing 210008, Jiangsu Province, China
Hai-Wei Zhang, Department of Rheumatology and Immunology, Nanjing Pukou People’s Hospital, Nanjing 211800, Jiangsu Province, China
Hong-Wei Chen, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of School of Medicine, Nanjing University, Nanjing 210008, Jiangsu Province, China
Author contributions: Xu M, Tian LL, Li XL, and Bao C wrote the manuscript; Zhang HW performed the research; Chen HW designed the review and were responsible for the final proofreading; All authors have read and approve the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 82271843; and Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health, No. ZKX20019.
Conflict-of-interest statement: All authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Chen, PhD, Associate Professor, Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of School of Medicine, Nanjing University, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. chenhw@nju.edu.cn
Received: October 12, 2023 Revised: February 27, 2024 Accepted: April 9, 2024 Published online: June 20, 2024 Processing time: 251 Days and 3.7 Hours
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which multiple organs are damaged that prevails in fertile women. Currently, glucocorticoids and immunosuppressants are widely used to treat SLE patients. However, ovarian dysfunction occurs following the use of these drugs in women with SLE. Here, we summarize recent progress in terms of understanding ovarian injury, the effects of drug application and strategies to improve ovarian function in women with SLE. This review could be helpful to precisely cure SLE in women desiring to have offspring.
Core Tip: Systemic lupus erythematosus (SLE) is an autoimmune disease that often occurs in women of childbearing age. Disorders of the immune system and clinical treatment drugs can affect the ovarian and reproductive functions of female patients. Herein, we summarize the research progress on SLE combined with ovarian dysfunction, hoping to provide a reference for the clinical treatment of patients with SLE for ovarian function and fertility needs.
