Opinion Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Mar 20, 2024; 14(1): 89320
Published online Mar 20, 2024. doi: 10.5493/wjem.v14.i1.89320
Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes
Charalampos Milionis, Ioannis Ilias, Anastasia Lekkou, Evangelia Venaki, Eftychia Koukkou
Charalampos Milionis, Ioannis Ilias, Anastasia Lekkou, Evangelia Venaki, Eftychia Koukkou, Department of Endocrinology, Diabetes, and Metabolism, ‘Elena Venizelou’ General Hospital, Athens 11521, Greece
Author contributions: Milionis C conceived the subject of the paper, prepared and revised the text, and approved the final version of the article; Ilias I and Lekkou A provided feedback on the content of the paper, made amendments to the text, and approved the final version of the article; Koukkou E and Venaki E supervised the writing of the paper, guided the revisions, and approved the final version of the article.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Charalampos Milionis, MD, PhD, Consultant Physician-Scientist, Department of Endocrinology, Diabetes, and Metabolism, ‘Elena Venizelou’ General Hospital, Elena Venizelou Square 2, Athens 11521, Greece. pesscharis@hotmail.com
Received: October 27, 2023
Peer-review started: October 27, 2023
First decision: November 30, 2023
Revised: December 11, 2023
Accepted: December 28, 2023
Article in press: December 28, 2023
Published online: March 20, 2024
Processing time: 143 Days and 21.4 Hours
Core Tip

Core Tip: Understanding the diagnostic role of C-peptide measurements in predicting hyperglycemia during pregnancy can facilitate timely interventions in clinical practice, potentially preventing gestational diabetes in a subset of predisposed women. Further research is necessary to confirm the utility of C-peptide testing in pregnancy and define the appropriate diagnostic thresholds.