©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Aug 20, 2015; 5(3): 182-187
Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.182
Published online Aug 20, 2015. doi: 10.5493/wjem.v5.i3.182
Computed tomography-based finite element analysis to assess fracture risk and osteoporosis treatment
Kazuhiro Imai, Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, Tokyo 153-8902, Japan
Author contributions: Imai K contributed to this paper.
Supported by Japan Society for the Promotion of Science KAKENHI, No. 26462284.
Conflict-of-interest statement: Kazuhiro Imai has received research funding from Teijin Pharma Limited.
Correspondence to: Kazuhiro Imai, MD, PhD, Associate Professor, Department of Life Sciences, Graduate School of Arts and Sciences, the University of Tokyo, 3-8-1, Komaba, Meguro-ku, Tokyo 153-8902, Japan. imaik-ort@umin.ac.jp
Telephone: +81-3-54546861 Fax: +81-3-54544317
Received: September 27, 2014
Peer-review started: September 28, 2014
First decision: November 14, 2014
Revised: April 23, 2015
Accepted: May 7, 2015
Article in press: May 8, 2015
Published online: August 20, 2015
Processing time: 332 Days and 12.6 Hours
Peer-review started: September 28, 2014
First decision: November 14, 2014
Revised: April 23, 2015
Accepted: May 7, 2015
Article in press: May 8, 2015
Published online: August 20, 2015
Processing time: 332 Days and 12.6 Hours
Core Tip
Core tip: Finite element analysis (FEA) is a computer technique of structural stress analysis developed in engineering mechanics. With the faster computers, better FEA, using computed tomography (CT) has been developed. This CT-based finite element analysis (CT/FEA) has provided clinicians with useful data. In this review, the mechanism of CT/FEA, validation studies of CT/FEA to evaluate accuracy and reliability in human bones, and clinical application studies to assess fracture risk and osteoporosis treatment are overviewed.