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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Dec 20, 2025; 15(4): 108702
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.108702
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.108702
Ganglion cell complex and retinal nerve fiber layer thickness in predicting visual outcome in brain tumors after surgery
Sucheta Parija, Bhagabat Nayak, Department of Ophthalmology, All India Institute of Medical Sciences, Bhubaneshwar 751019, Odisha, India
Koyel Chakraborty, Department of Ophthalmology, All India Institute of Medical Sciences Kalyani, Kolkota 741245, West Bengal, India
Rabi Narayan Sahu, Department of Neurosurgery, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar 751019, Odisha, India
Ravikumar Subraya Rathod, Department of Community Medicine, Government Medical College and Hospital, Chandigarh 160030, Chandīgarh, India
Co-first authors: Sucheta Parija and Koyel Chakraborty.
Author contributions: Parija S contributed to conceptualization of idea, writing and editing; Chakraborty K contributed to data collection, writing and editing; Sahu RN contributed to data collecting, editing; Nayak B contributed to editing of article; Rathod RS contributed to statistical analysis and formatting.
Institutional review board statement: The approval of this ethics protocol was granted by the All India Institute of Medical Sciences.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: No data shared.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sucheta Parija, Head, Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Patrapada, Bhubaneshwar 751019, Odisha, India.
Received: April 22, 2025
Revised: June 10, 2025
Accepted: September 16, 2025
Published online: December 20, 2025
Processing time: 242 Days and 11.9 Hours
Revised: June 10, 2025
Accepted: September 16, 2025
Published online: December 20, 2025
Processing time: 242 Days and 11.9 Hours
Core Tip
Core Tip: This study was conducted among perichiasmatic brain tumor patients in which optical coherence tomography was used to detect ganglion cell complex (GCC) and retinal nerve fibre layer (RNFL) damage as well as prognosticate visual outcome. A positive correlation was noted between GCC thickness, visual acuity and field defect at six months postoperatively. The predictors of blindness were reduced baseline GCC and RNFL thickness. A minimum cut-off value predicting preservation of vision was a RNFL thickness of 73 µm and a GCC thickness of 58 µm. Hence, it can guide early intervention by a neurosurgeon for vision preservation.