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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Exp Med. Dec 20, 2025; 15(4): 108221
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.108221
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.108221
Bacteria in neoplastic diseases: A brief note on Wilms tumor
Adam Burke, Department of Family Medicine, Independence Health System, Latrobe, PA 15650, United States
Adekunle Sanyaolu, Amitabha Ray, Biomedical Sciences, School of Health Professions, D’Youville University, Buffalo, NY 14201, United States
Co-corresponding authors: Adekunle Sanyaolu and Amitabha Ray.
Author contributions: Ray A contributed to the study conception and designed the review; Burke A, Sanyaolu A, and Ray A performed the literature search, analysis, drafting, critical revision, and editing; Ray A supervised the complete article; and all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Adekunle Sanyaolu, PhD, Professor, Biomedical Sciences, D’Youville University, 320 Porter Ave, Buffalo, NY 14201, United States. sanyakunle@hotmail.com
Received: April 9, 2025
Revised: May 12, 2025
Accepted: August 4, 2025
Published online: December 20, 2025
Processing time: 255 Days and 10.7 Hours
Revised: May 12, 2025
Accepted: August 4, 2025
Published online: December 20, 2025
Processing time: 255 Days and 10.7 Hours
Core Tip
Core Tip: This review describes different aspects of Wilms tumor, e.g., pathogenesis, epidemiology, immune responses, and complications, particularly secondary bacterial infections. The pertinent Wilms tumor 1 (WT1) gene and its protein play an important role in the embryogenesis of the kidney and the development of Wilms tumor. Interestingly, WT1 functions both as a tumor suppressor as well as an oncogenic factor, probably depending on the biological circumstances. Nevertheless, WT1 is overexpressed in several tumor tissues. For this reason, WT1-targeted strategies are potential areas in cancer therapy.