Efficacy and safety of exosomes from Wharton’s Jelly-derived mesenchymal stem cells in traumatic brain injury

Table 1 Administration schedule

Rounds	Route	Exosomes from Wharton’s Jelly-derived mesenchymal stem cells
Round 1	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 2 (week 2)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 3 (week 6)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 4 (week 10)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 5 (week 14)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL
Round 6 (week 18)	IT	30 × 109 exosomes in 3 mL
	IM	30 × 109 exosomes in 3 mL

IM: Intramuscular; IT: Intrathecally;

Table 2 Friedman test results for the change in functional independence measure motor score values of patients before and after the intervention

	n	Mean	SD	Mean rank	χ2	df	P value
Preoperative	5	46.20	16.39	1.40	24.883	5	0.000
Postoperative 1st week	5	46.60	16.23	1.60
Postoperative 1st month	5	52.00	17.01	3.00
Postoperative 2nd month	5	55.20	17.81	4.00
Postoperative 4th month	5	58.80	18.95	5.00
Postoperative 12th month	5	64.20	18.90	6.00

Table 3 Friedman test results for the change in functional independence measure cognitive score values of patients before and after the intervention

	n	Mean	SD	Mean rank	χ2	df	P value
Preoperative	5	30.60	4.56	2.30	14.898	5	0.011
Postoperative 1st week	5	30.60	4.56	2.30
Postoperative 1st month	5	32.00	3.46	3.50
Postoperative 2nd month	5	32.00	3.46	3.50
Postoperative 4th month	5	33.40	2.30	4.50
Postoperative 12th month	5	34.00	1.41	4.90

Table 4 Friedman test results for the change in modified Ashworth Grading Right Values of patients before and after the intervention

	n	Mean	SD	Mean rank	χ2	df	P value
Preoperative	5	4.60	7.40	4.30	9.688	5	0.085
Postoperative 1st week	5	4.60	7.40	4.30
Postoperative 1st month	5	3.80	6.50	3.70
Postoperative 2nd month	5	3.00	5.20	3.10
Postoperative 4th month	5	2.40	3.91	2.90
Postoperative 12th month	5	2.20	3.49	2.70

Table 5 Friedman test results for the change in modified Ashworth Grading Left Values of patients before and after the intervention

	n	Mean	SD	Mean rank	χ2	df	P value
Preoperative	5	3.60	4.93	4.30	9.615	5	0.087
Postoperative 1st week	5	3.60	4.93	4.30
Postoperative 1st month	5	2.60	3.58	3.60
Postoperative 2nd month	5	2.40	3.29	3.30
Postoperative 4th month	5	2.00	2.83	2.90
Postoperative 12th month	5	1.60	2.19	2.60

Table 6 Friedman test results for the changes in Karnofsky Performance Scale Values of patients before and after the intervention

	n	Mean	SD	Mean rank	χ2	df	P value
Preoperative	5	46.00	11.402	1.80	23.526	5	0.000
Postoperative 1st week	5	46.00	11.402	1.80
Postoperative 1st month	5	50.00	7.071	2.50
Postoperative 2nd month	5	60.00	12.247	4.10
Postoperative 4th month	5	66.00	11.402	5.00
Postoperative 12th month	5	72.00	8.367	5.80