Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Crit Care Med. Sep 9, 2026; 15(3): 120168
Published online Sep 9, 2026. doi: 10.5492/wjccm.120168
Published online Sep 9, 2026. doi: 10.5492/wjccm.120168
Letter to the Editor: Magnesium supplementation in sepsis: A promising metabolic resuscitation strategy
Damodar Paudel, Department of Medicine, Nepal Police Hospital, Kathmandu 44600, Bāgmatī, Nepal
Damodar Paudel, Department of Internal Medicine, Nepal Police Hospital, Kathmandu 44600, Bāgmatī, Nepal
Author contributions: Paudel D confirms sole responsibility for all aspects of the editorial, including conception, drafting, and final approval.
Conflict-of-interest statement: The author has no conflict of interest related to the manuscript.
Corresponding author: Damodar Paudel, MD, MSc, Department of Medicine, Nepal Police Hospital, Maharjgunj, Kathmandu 44600, Bāgmatī, Nepal. damodarpaudel@gmail.com
Received: February 24, 2026
Revised: March 30, 2026
Accepted: April 24, 2026
Published online: September 9, 2026
Processing time: 185 Days and 13.6 Hours
Revised: March 30, 2026
Accepted: April 24, 2026
Published online: September 9, 2026
Processing time: 185 Days and 13.6 Hours
Core Tip
Core Tip: Magnesium is a key co factor in ATP synthesis and mitochondrial electron transport and plays an important role in immune metabolic regulation. Hypomagnesemia impairs cellular energy metabolism and contributes to lactate accumulation, while hepatic dysfunction further compromises lactate clearance. Together, these mechanisms may exacerbate lactic acidosis and worsen outcomes in septic patients.