Paulin S, Palaniappan R. Brain-kidney cross-talk: A call for action! World J Crit Care Med 2026; 15(2): 115116 [DOI: 10.5492/wjccm.v15.i2.115116]
Corresponding Author of This Article
Susan Paulin, Consultant, Department of Liver Transplant Anesthesia and Critical Care, Dr Rela Institute and Medical Centre, No. 7 CLC works road, Nagappa Nagar, Chrompet, Chennai 600044, Tamil Nādu, India. susanvercetti@gmail.com
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Crit Care Med. Jun 9, 2026; 15(2): 115116 Published online Jun 9, 2026. doi: 10.5492/wjccm.v15.i2.115116
Brain-kidney cross-talk: A call for action!
Susan Paulin, Ratthinam Palaniappan
Susan Paulin, Department of Liver Transplant Anesthesia and Critical Care, Dr Rela Institute and Medical Centre, Chennai 600044, Tamil Nādu, India
Ratthinam Palaniappan, Department of Critical Care Medicine, Dr Rela Institute and Medical Centre, Chennai 600044, Tamil Nādu, India
Author contributions: Paulin S and Palaniappan R contributed to the writing and editing of the manuscript, illustrations, and review of literature; Paulin S designed the overall concept and outline of the manuscript; Palaniappan R contributed to the discussion and design of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Susan Paulin, Consultant, Department of Liver Transplant Anesthesia and Critical Care, Dr Rela Institute and Medical Centre, No. 7 CLC works road, Nagappa Nagar, Chrompet, Chennai 600044, Tamil Nādu, India. susanvercetti@gmail.com
Received: October 9, 2025 Revised: December 9, 2025 Accepted: January 19, 2026 Published online: June 9, 2026 Processing time: 224 Days and 19.5 Hours
Core Tip
Core Tip: Optimal management of traumatic brain injury requires moving beyond immediate neurological threats to address the profound systemic complications that often determine patient outcomes. The critical question remains: Does identification of predictors translate into effective prevention? A call for action is needed in refining hemodynamic targets, utilization of advanced hemodynamic monitoring, exploring predictive biomarkers, and developing Artificial Intelligence-based prediction models. Clinical focus must expand beyond the immediate neurological threats to address the full spectrum of traumatic brain injury pathophysiology to develop integrated, multi-organ therapeutic strategies and enhance patient outcomes with efficient resource utilization.
