Jatteppanavar B, Choudhury A, Panda PK, Bairwa M. Community-acquired multidrug-resistant pneumonia, bacteraemia, and infective endocarditis: A case report. World J Crit Care Med 2024; 13(1): 87459 [PMID: 38633471 DOI: 10.5492/wjccm.v13.i1.87459]
Corresponding Author of This Article
Prasan Kumar Panda, MBBS, MD, Associate Professor, Department of Medicine, All India Institute of Medical Sciences, Veer Bhadra Road, Rishikesh, Uttarkhand, 249203, India. motherprasanna@rediffmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Basavaraj Jatteppanavar, Arnab Choudhury, Prasan Kumar Panda, Mukesh Bairwa, Department of Medicine, All India Institute of Medical Sciences, Rishikesh 249203, India
Author contributions: Jatteppanavar B and Choudhury A contributed equally to this work; Jatteppanavar B, Choudhury A, Bairwa M, and Panda PK designed the research study, performed the research, and critically reviewed the manuscript; Jatteppanavar B and Choudhury A analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient in the study.
Conflict-of-interest statement: There are no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prasan Kumar Panda, MBBS, MD, Associate Professor, Department of Medicine, All India Institute of Medical Sciences, Veer Bhadra Road, Rishikesh, Uttarkhand, 249203, India. motherprasanna@rediffmail.com
Received: August 12, 2023 Peer-review started: August 12, 2023 First decision: September 28, 2023 Revised: October 3, 2023 Accepted: December 4, 2023 Article in press: December 4, 2023 Published online: March 9, 2024 Processing time: 201 Days and 2.3 Hours
Abstract
BACKGROUND
The prevalence of multidrug-resistant (MDR) bacteria has increased globally, with extensive drug-resistant (XDR) bacteria posing a threat to patients.
CASE SUMMARY
This case report describes a young man admitted for suspected tropical fever infections who experienced rapid deterioration in health. Despite negative results for tropical fever infections, he had neutrophilic leucocytosis, acute kidney injury, and chest imaging findings suggestive of bilateral consolidations. On day two, he was diagnosed with infective endocarditis with possible rheumatic heart disease and MDR methicillin-resistant Staphylococcus aureus bacteraemia, and community-acquired pneumonia. Despite treatment with broad-spectrum antibiotics, he did not respond and succumbed to death on day five.
CONCLUSION
This case highlights that clinicians/public should be aware of MDR community-acquired pneumonia, bacteraemia, and endocarditis which ultimately culminate in high rates of morbidity and mortality. Early identification of pathogenic strain and prompt antibiotic treatment are a mainstay for the management and prevention of early fatalities. Simultaneously, route cause analysis of community-acquired MDR/XDR pathogens is a global need.
Core Tip: A case of community-acquired multidrug-resistant methicillin-resistant Staphylococcus aureus infection leading to death is reported. The detection of CTX-M, VIM, NDM, mecA/C, and MREJ genes in microbial gene testing suggests that the patient was infected with MDR bacteria.
