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World J Crit Care Med. Jan 9, 2022; 11(1): 22-32
Published online Jan 9, 2022. doi: 10.5492/wjccm.v11.i1.22
Acute exacerbation of interstitial lung disease in the intensive care unit
Antonios Charokopos, Teng Moua, Jay H Ryu, Nathan J Smischney
Antonios Charokopos, Teng Moua, Jay H Ryu, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, United States
Nathan J Smischney, Department of Anesthesiology and Perioperative Medicine, Division of Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: All authors contributed to the writing, review and intellectual content of the paper.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nathan J Smischney, MD, MSc, Assistant Professor, Department of Anesthesiology and Perioperative Medicine, Division of Critical Care Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. smischney.nathan@mayo.edu
Received: March 9, 2021
Peer-review started: March 14, 2021
First decision: July 18, 2021
Revised: August 4, 2021
Accepted: November 15, 2021
Article in press: November 15, 2021
Published online: January 9, 2022
Processing time: 301 Days and 12.2 Hours
Abstract

Acute exacerbations of interstitial lung disease (AE-ILD) represent an acute, frequent and often highly morbid event in the disease course of ILD patients. Admission in the intensive care unit (ICU) is very common and the need for mechanical ventilation arises early. While non-invasive ventilation has shown promise in staving off intubation in selected patients, it is unclear whether mechanical ventilation can alter the exacerbation course unless it is a bridge to lung transplantation. Risk stratification using clinical and radiographic findings, and early palliative care involvement, are important in ICU care. In this review, we discuss many of the pathophysiological aspects of AE-ILD and raise the hypothesis that ventilation strategies used in acute respiratory distress syndrome might be implemented in AE-ILD. We present possible decision-making and management algorithms that can be used by the intensivist when caring for these patients.

Keywords: Interstitial lung diseases; Disease exacerbation; Mechanical ventilation; Intensive care unit; Pathophysiological aspect

Core Tip: During the acute and morbid event of acute exacerbation of interstitial lung disease, an intensivist needs to understand the pathophysiology and reversible causes of acute exacerbations, the diagnostics and treatments that are usually recommended, and the experimental therapies on the horizon. More importantly, the intensivist needs to be able to risk stratify the patients, selectively pursue mechanical ventilation, minimize ventilator induced lung injury, and involve palliative care early in non-lung transplant candidates.