Marik A, Biswas S, Banerjee ER. Exploring the relationship between gut microbial ecology and inflammatory disease: An insight into health and immune function. World J Immunol 2024; 14(1): 96209 [DOI: 10.5411/wji.v14.i1.96209]
Corresponding Author of This Article
Ena Ray Banerjee, DSc, Professor, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. enarb1@gmail.com
Research Domain of This Article
Immunology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Immunol. Jul 25, 2024; 14(1): 96209 Published online Jul 25, 2024. doi: 10.5411/wji.v14.i1.96209
Exploring the relationship between gut microbial ecology and inflammatory disease: An insight into health and immune function
Akashlina Marik, Saheli Biswas, Ena Ray Banerjee
Akashlina Marik, Saheli Biswas, Ena Ray Banerjee, Department of Zoology, University of Calcutta, Kolkata 700019, West Bengal, India
Co-first authors: Akashlina Marik and Saheli Biswas.
Author contributions: Ray Banerjee E conceptualized and wrote the manuscript; Marik A and Biswas S did the literature survey, designed and wrote the manuscript.
Supported byCouncil of Scientific and Industrial Research (CSIR), New Delhi; Department of Zoology, University of Calcutta for Infrastructural Support.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ena Ray Banerjee, DSc, Professor, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, West Bengal, India. enarb1@gmail.com
Received: April 29, 2024 Revised: May 29, 2024 Accepted: June 27, 2024 Published online: July 25, 2024 Processing time: 86 Days and 13.5 Hours
Abstract
The immune system, host brain development, and general metabolism are all influenced by the gut bacteria. Bacteria make up the majority of the gut microbiota in mammals. The mouse has been the most often used animal model in preclinical biological research. In mice, Firmicutes and Clostridiales are prominent. On the other hand, Bacteroidaceae, Prevotellaceae, and Firmicutes are commonly found in humans. In this review, we performed a detailed study by focusing on a comparison between human and murine gut microbiomes, role of the microbiome and their secreted metabolites in regulating gut immunity to maintain homeostasis, and changes in the microbial composition in the dysbiotic state.
Core Tip: The gut microbiome is a complex assemblage of microorganisms consisting of bacteria, archaea, fungi which inhabits the gut and are responsible for carrying out various functions like digestion of complex food components, synthesis of vitamins, stimulation of immune response and strengthening of gut barrier and protection from pathogens. Metabolites secreted by these bacteria play an important role in homeostasis and in maintaining a healthy state in the host. Dysbiosis of the intricately woven ecological networks in the gut microbiome plays a critical role in various health-related disorders like diabetes, obesity, and inflammatory bowel disease.
