Research on gamma globulin unresponsive Kawasaki disease: A review

Table 1 Core pathological features and key mechanisms of Kawasaki disease

Pathological features/mechanisms	Description
Core pathological features
Systemic vasculitis	Inflammation of blood vessels throughout the body
Specific involvement of coronary arteries	High risk of coronary artery aneurysms and other complications
Key mechanisms
Abnormal immune system activation	Overproduction of inflammatory cytokines leading to vascular damage
Infection trigger hypothesis	Possible role of viral or bacterial infections in initiating the immune response
Genetic susceptibility	Specific genetic variants increasing the risk of developing Kawasaki disease
Endothelial cell dysfunction	Damage to endothelial cells causing increased vascular permeability and blood clot formation