Diagnostic and prognostic utility of D-dimer and heparin-binding protein in neonatal sepsis: A prospective case-control study

Figure 1 Serological parameters of sepsis in the different studied groups. A: C-reactive protein; B: D-dimer; C: Heparin binding protein; D: White blood cells; E: Neutrophils; F: Platelets. Box and Whiskers plot. Minimum, 25^th percentile, median, 75^th percentile, and maximum are indicated. Horizontal line represents P value between the designated groups. The asterisk represents outliers. mean ± SD are plotted. CRP: C-reactive protein; HBP: Heparin binding protein; WBCs: White blood cells.

Figure 2 Performance of serological markers in discriminating sepsis. A: C reactive protein; B: D-dimer; C: Heparin binding protein. Sensitivity is plotted on Y axis and specificity on X axis. Performance percentages are in the lower right box. Selection of cutoff values is based on the best performance (highest sensitivity and specificity simultaneously). AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value.

Figure 3 Performance of mortality predictors. A: D-dimer; B: Neonatal sequential organ failure assessment. Sensitivity is plotted on Y axis and specificity on X axis. Performance percentages are in the lower right box. Selection of cutoff values is based on the best performance (highest sensitivity and specificity simultaneously). nSOFA: Neonatal sequential organ failure assessment; AUC: Area under the curve; PPV: Positive predictive value; NPV: Negative predictive value.