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World J Clin Pediatr. Jun 9, 2026; 15(2): 112072
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.112072
Published online Jun 9, 2026. doi: 10.5409/wjcp.v15.i2.112072
Impact of breast milk composition on nutritional status of term neonates with congenital heart defects: A prospective study
Aleksandra V Kaplina, Tatiana A Fedoseeva, Tatiana M Pervunina, Natalia A Petrova, Institution of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia
Olga V Kalinina, Institute of Molecular Biology and Genetics, Department of Laboratory Medicine with Clinic, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia
Olga O Shemyakina, Tatiana G Barakova, Maria V Kim, Department of Neonatal Physiology with an ICU Ward, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia
Author contributions: Kaplina AV designed and conducted the study, collected the data, analyzed and interpreted the data, and drafted the initial manuscript; Fedoseeva TA contributed to the analyses; Barakova TG and Kim MV provided clinical advice; Pervunina TM and Petrova NA contributed to project administration and funding acquisition; Kalinina OV participated in data analysis and interpretation; Shemyakina OO designed the study; Petrova NA designed and supervised the study and drafted the initial manuscript; All authors contributed to manuscript editing and approved the final version of the manuscript.
Supported by Ministry of Health of Russia, No. LPUH-2025-0054.
Institutional review board statement: This study was approved by the local institutional Ethics Committee (protocol No. 1505-25) and conducted in accordance with the principles outlined in the Declaration of Helsinki.
Informed consent statement: Written informed consent was obtained from all mothers who participated in the study.
Conflict-of-interest statement: The authors declare no competing interests.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Aleksandra V Kaplina, Institution of Perinatology and Pediatrics, Almazov National Medical Research Centre, Akkuratova Str 2, Saint-Petersburg 197341, Russia. kaplinashi@gmail.com
Received: July 17, 2025
Revised: August 25, 2025
Accepted: December 1, 2025
Published online: June 9, 2026
Processing time: 300 Days and 22 Hours
Revised: August 25, 2025
Accepted: December 1, 2025
Published online: June 9, 2026
Processing time: 300 Days and 22 Hours
Core Tip
Core Tip: This single-center prospective non-interventional study evaluated breast milk composition in mothers of neonates with congenital heart defects and its relationship with neonatal nutritional status. The colostrum fat concentration was significantly lower in mothers of operated neonates than in mothers of non-operated neonates. Operated neonates showed a decline in weight-for-age z score (WAZ) from preoperative values to discharge. The delayed achievement of full enteral feeding postoperatively independently predicted WAZ decline while higher calorie and fat intake on postoperative day 14 was associated with less WAZ reduction. In operated neonates higher colostrum protein content correlated with early weight gain.