©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
World J Clin Pediatr. Mar 9, 2026; 15(1): 114465
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.114465
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.114465
Efficacy of vitamin D supplementation for children with acute bronchiolitis: A randomized controlled trial
Elsayed Abdelkreem, Yostena Safwat Labeeb, Mostafa Ashry Mohamed, Department of Pediatrics, Faculty of Medicine, Sohag University, Nasser City 82524, Sohag, Egypt
Elsayed Abdelkreem, Department of Clinical Sciences, Al Rayan National College of Medicine, Al Madinah Al Munawarah 41411, Saudi Arabia
Author contributions: Abdelkreem E conceived and designed the study, shared in methodology, interpreted data, and wrote manuscript draft; Labeeb YS shared in study methodology, data analysis, and manuscript editing; Mohamed MA designed the study, shared in methodology, and revised the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Research Ethics Committee of Faculty of Medicine, Sohag University (Approval No. Soh-Med-23-03-11MS; dated March 8, 2023).
Clinical trial registration statement: This study has been registered at https://clinicaltrials.gov/study/NCT05795933 (ID: NCT05795933).
Informed consent statement: Parents or legally authorized representatives of all participating children provided written informed consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Elsayed Abdelkreem, MD, PhD, Assistant Professor, Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag University Street, Nasser City 82524, Sohag, Egypt. d.elsayedmohammed@med.sohag.edu.eg
Received: September 22, 2025
Revised: October 20, 2025
Accepted: December 3, 2025
Published online: March 9, 2026
Processing time: 167 Days and 22.6 Hours
Revised: October 20, 2025
Accepted: December 3, 2025
Published online: March 9, 2026
Processing time: 167 Days and 22.6 Hours
Core Tip
Core Tip: Vitamin D deficiency has been linked to bronchiolitis, yet the therapeutic benefit of supplementation remains uncertain. In this randomized controlled trial, a single intramuscular dose of 200000 IU vitamin D3 significantly shortened hospital stay and reduced oxygen and intravenous fluid requirements in children with bronchiolitis who were vitamin D deficient, but not in those with sufficient levels. These results suggest that targeted supplementation may improve outcomes in deficient children, supporting a test-and-treat strategy.