Sabitova G, Makhammajanov Z, Khvan M, Tarlykov P, Sazonov V. Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis. World J Clin Pediatr 2026; 15(1): 114054 [DOI: 10.5409/wjcp.v15.i1.114054]
Corresponding Author of This Article
Vitaliy Sazonov, MD, Assistant Professor, Department of Surgery, School of Medicine, Nazarbayev University, Kabanbay Batyr 53, Astana Z05K4F4, Kazakhstan. vitaliy.sazonov@nu.edu.kz
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Pediatrics
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Systematic Reviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 9, 2026 (publication date) through Mar 9, 2026
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Publication Name
World Journal of Clinical Pediatrics
ISSN
2219-2808
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Sabitova G, Makhammajanov Z, Khvan M, Tarlykov P, Sazonov V. Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis. World J Clin Pediatr 2026; 15(1): 114054 [DOI: 10.5409/wjcp.v15.i1.114054]
World J Clin Pediatr. Mar 9, 2026; 15(1): 114054 Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.114054
Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis
Guldana Sabitova, Zhalaliddin Makhammajanov, Marina Khvan, Pavel Tarlykov, Vitaliy Sazonov
Guldana Sabitova, Zhalaliddin Makhammajanov, Marina Khvan, Department of Medicine, School of Medicine, Nazarbayev University, Astana Z05K4F4, Kazakhstan
Pavel Tarlykov, Department of Proteomics and Mass Spectrometry, National Center for Biotechnology, Astana Z05K4F4, Kazakhstan
Vitaliy Sazonov, Department of Surgery, School of Medicine, Nazarbayev University, Astana Z05K4F4, Kazakhstan
Vitaliy Sazonov, Pediatric Anesthesiology and Intensive Care Unit, Mother and Child Center, University Medical Center, Astana Z05K4F4, Kazakhstan
Author contributions: Sabitova G wrote the original draft; Sabitova G and Sazonov V designed the research study; Makhammajanov Z was responsible for developing the methodology; Makhammajanov Z and Sazonov V participated in the review and editing; Khvan M and Tarlykov P participated in the formal analysis and investigation; all authors have read and approved the submitted version.
Supported by Nazarbayev University Faculty Development Grant for 2025-2027, No. 040225FD4716.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Vitaliy Sazonov, MD, Assistant Professor, Department of Surgery, School of Medicine, Nazarbayev University, Kabanbay Batyr 53, Astana Z05K4F4, Kazakhstan. vitaliy.sazonov@nu.edu.kz
Received: September 11, 2025 Revised: September 29, 2025 Accepted: November 24, 2025 Published online: March 9, 2026 Processing time: 177 Days and 4 Hours
Core Tip
Core Tip: Pediatric sepsis requires rapid and reliable “rule-in” tools upon presentation. This systematic review summarizes four pediatric proteomics studies and presents a practical pathway. Single markers, such as interleukin-27, serum amyloid A 1, soluble CD25, and leucine-rich alpha-2-glycoprotein 1, demonstrate high specificity for early diagnosis. The infant-focused combination of haptoglobin and thrombospondin 1 improves short-term risk stratification. We explain why age matters: Noting that immune maturation shifts effect sizes and may necessitate age-adjusted cut-points and neonatal-specific panels. We also map discovery platforms (aptamer/mass spectrometry) to rapid 3-5-plex immunoassays that are suitable for emergency department and pediatric intensive care unit use. Rather than offering pooled estimates, the systematic review provides translational guidance aimed at accelerating the deployment of clinically useful pediatric sepsis testing.
