©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study
Magd A Kotb, Manal M Wilson, Amani N Shafik, Noura A Ahmed, Veronia F Fahim, Nabil A Lotfi, Yasmin MR Eissawy
Magd A Kotb, Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Cairo 4240310, Egypt
Manal M Wilson, Department of Clinical Pathology, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Amani N Shafik, Veronia F Fahim, Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo 11956, Egypt
Noura A Ahmed, Department of Pediatrics, Medical Insurance Hospital, Suez 43511, Egypt
Nabil A Lotfi, House Officer, Faculty of Medicine, Cairo University, Cairo 4240310, Egypt
Yasmin MR Eissawy, Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo 12613, Egypt
Author contributions: Kotb MA conceived the project; Kotb MA, Wilson MM, and Eissawy YMR supervised the work; Kotb MA, Wilson MM, and Ahmed NA performed clinical/Laboratory work; Kotb MA, Wilson MM, Shafik AN, Ahmed NA, Fahim VF, Lotfi NA, and Eissawy YMR analyzed data, conducted literature review, and drafted and appraised the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Research and Higher Education of Faculty of Medicine, Cairo University, approval No. MS-487-2021.
Informed consent statement: All study participants, or their legal guardians, provided informed written consent before enrollment in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Corresponding author: Veronia F Fahim, PhD, Lecturer, Department of Medical Phar
macology, Faculty of Medicine, Cairo University, Kasr El Ainy St., Kasr-Alainy, El Manial, Cairo 11956, Egypt.
veronia.fawzy@kasralainy.edu.eg
Received: August 27, 2025
Revised: September 28, 2025
Accepted: December 15, 2025
Published online: March 9, 2026
Processing time: 192 Days and 0.6 Hours
