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World J Clin Pediatr. Mar 9, 2026; 15(1): 113155
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.113155
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.113155
Longitudinal extensive anti-AMPA-GluR3-related transverse myelitis and favorable therapeutic response: A case report and review of literature
Maria Elena Cucuzza, Maria T Garozzo, Maria C Finocchiaro, Vita A Di Stefano, Department of Pediatric Unit and Pediatric Emergency Room, Emergency Hospital Cannizzaro, Catania 95100, Italy
Piero Pavone, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania 95100, Italy
Filippo Greco, Pierluigi Smilari, Alessandra Di Nora, Martino Ruggieri, Department of Clinical and Experimental Medicine, Pediatric Clinic, University of Catania, Catania 95100, Italy
Author contributions: Cucuzza ME and Garozzo MT acquisition of data and drafting the article; Cucuzza ME and Pavone P analysis and interpretation of data; Cucuzza ME conception and design; Pavone P drafting and revising the article critically for important intellectual content; Finocchiaro MC, Greco F, Smilari P, Di Nora A, Ruggieri M, and Di Stefano VA formal analysis and investigation.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Maria Elena Cucuzza, DM, Department of Pediatric Unit and Pediatric Emergency Room, Emergency Hospital Cannizzaro, Via Messina 829, Catania 95100, Italy.
Received: August 18, 2025
Revised: September 16, 2025
Accepted: December 1, 2025
Published online: March 9, 2026
Processing time: 202 Days and 2.7 Hours
Revised: September 16, 2025
Accepted: December 1, 2025
Published online: March 9, 2026
Processing time: 202 Days and 2.7 Hours
Core Tip
Core Tip: This case report describes a potential link between longitudinally extensive transverse myelitis (LETM) and high levels of GluR3abs receptor 3 in a 5-year-old girl. LETM is a neurological disorder marked by a spinal cord lesion spanning three or more vertebral segments. The girl presented with lower back pain, bilateral sensory, motor impairments, and autonomic dysfunction. She had a positive response to high doses of intravenous methylprednisolone and immunoglobulin therapy. The frequency of LETM associated with GluR3abs is unknown, but this case could help expand understanding of this rare condition.