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World J Clin Pediatr. Mar 9, 2026; 15(1): 108069
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.108069
Published online Mar 9, 2026. doi: 10.5409/wjcp.v15.i1.108069
Vaping during pregnancy and its impact on neonatal outcomes: A systematic review and meta-analysis
Maneeth Mylavarapu, Department of Cardiology, Endeavor Health Cardiovascular Institute, Glenview, IL 60026, United States
Sree Mahathi Chavali, Department of Pediatrics, New York Presbyterian Methodist Hospital, Brooklyn, NY 11215, United States
Ananya D Buddharaju, Department of Pediatrics, ESIC Medical College and Hospital, Hyderabad 500038, Telangāna, India
Sruthi Veldurthy, Department of Pediatrics, Mediciti Institute of Medical Sciences, Ghanpur 501401, Telangāna, India
Pratyusha Cheruvu, Department of Pediatrics, Gandhi Medical College, Secunderabad 500003, Telangāna, India
Abhinav G Parikh, Department of Neonatology, New York Presbyterian Methodist Hospital, Brooklyn, NY 11215, United States
Co-first authors: Maneeth Mylavarapu and Sree Mahathi Chavali.
Author contributions: Mylavarapu M and Chavali M contributed to the design and implementation of the study and supervision; Mylavarapu M, Chavali M, Buddharaju AD, Veldurthy S, and Cheruvu NP contributed to the methodology, including the statistical analyses; Mylavarapu M contributed to visualization; Mylavarapu M, Chavali M, Buddharaju AD, Veldurthy S, Cheruvu NP, and Parikh AG contributed to writing the manuscript; Mylavarapu M, Chavali M, and Parikh AG contributed to reviewing and editing the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA checklist of items, and the manuscript was prepared and revised according to the PRISMA checklist of items.
Corresponding author: Maneeth Mylavarapu, MD, AI Cardiology, Advanced Imaging Research Fellow, Department of Cardiology, Endeavor Health Cardiovascular Institute, Glenview, IL 60026, United States. dr.maneeth.mylavarapu@gmail.com
Received: April 8, 2025
Revised: May 29, 2025
Accepted: November 5, 2025
Published online: March 9, 2026
Processing time: 336 Days and 7.9 Hours
Revised: May 29, 2025
Accepted: November 5, 2025
Published online: March 9, 2026
Processing time: 336 Days and 7.9 Hours
Core Tip
Core Tip: Vaping during pregnancy is associated with significantly increased odds of low birth weight and small for gestational age, highlighting potential adverse neonatal outcomes. Pregnant individuals who vape, despite a lower overall prevalence, face heightened risks for these complications. These findings underscore the need for targeted public health interventions and further research to understand the long-term impacts of prenatal e-cigarette exposure.