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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Dec 9, 2025; 14(4): 112145
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.112145
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.112145
Modulatory role of vitamin D in atopic dermatitis and allergic rhinitis
Chandra Sekhar Devulapalli, Department of Medicine, Pediatric Outpatient Clinic, Helgeland Hospital, Alstahaug (Sandnessjøen) NO-8800, Nordland, Norway
Author contributions: Devulapalli CS wrote this article.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chandra Sekhar Devulapalli, MD, PhD, Consultant, Senior Researcher, Senior Scientist, Department of Medicine, Pediatric Outpatient Clinic, Helgeland Hospital, Prestmarkveien 1, Alstahaug (Sandnessjøen) NO-8800, Nordland, Norway.
Received: July 21, 2025
Revised: August 7, 2025
Accepted: September 17, 2025
Published online: December 9, 2025
Processing time: 105 Days and 7.6 Hours
Revised: August 7, 2025
Accepted: September 17, 2025
Published online: December 9, 2025
Processing time: 105 Days and 7.6 Hours
Core Tip
Core Tip: Vitamin D has emerged as a key modulator of immune responses and epithelial barrier integrity relevant to pediatric atopic dermatitis and allergic rhinitis (AR). Recent evidence highlights phenotype-specific effects, particularly in children with allergic sensitization, and suggests stronger associations with seasonal AR. Advances in vitamin D receptor biology and genomics support a personalized approach to supplementation. Early-life vitamin D exposure may influence immune development and disease trajectory, underscoring the potential for preventive and therapeutic applications in pediatric allergy care.