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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Dec 9, 2025; 14(4): 108329
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.108329
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.108329
Arrhythmogenic cardiomyopathy in children, on the link between injurious mutations and inflammation: Two case reports and review of the literature
Ekaterina Nikitina, Anna Zlotina, Alexey Golovkin, Olga Kalinina, Anna Kostareva, Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia
Olga Kofeynikova, Tatiana Pervunina, Elena Vasichkina, Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia
Olga Kalinina, Department of Laboratory Medicine with Clinic, Institution of Medical Edu
Co-corresponding authors: Olga Kalinina and Anna Kostareva.
Author contributions: Nikitina E collected, analyzed and interpreted the data, drafted the initial manuscript; Kofeynikova O contributed to the data collection process and clinical advice; Pervunina T and Vasichkina E provided clinical advice and conceptualized the study; Golovkin A participated in data analysis and interpretation; Zlotina A and Kalinina O contributed to project administration and funding acquisition; Kostareva A and Kalinina O conceptualized the study, analyzed and interpreted the data, drafted the initial manuscript; Kalinina O and Kostareva A have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; all authors contributed to manuscript editing and approved final version of the manuscript.
Supported by Russian Science Foundation, No. 24-15-20026/12.04.2024; and St. Petersburg Research Foundation, No. 24-15-20026/24.05.2024.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anna Kostareva, MD, Director, Professor, Institute of Molecular Biology and Genetics, Almazov National Medical Research Centre, Akkuratova Street 2, Saint-Petersburg 197341, Russia. anna.kostareva@ki.se
Received: April 11, 2025
Revised: May 5, 2025
Accepted: July 15, 2025
Published online: December 9, 2025
Processing time: 203 Days and 22.8 Hours
Revised: May 5, 2025
Accepted: July 15, 2025
Published online: December 9, 2025
Processing time: 203 Days and 22.8 Hours
Core Tip
Core Tip: Arrhythmogenic cardiomyopathy (ACM) is characterized by intercalated disc remodeling and cardiomyocytes death, which can lead to fibro-fatty replacement and severe heart failure. In some children, ACM presents with a “hot phase” and may be mistaken for acute myoca