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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Dec 9, 2025; 14(4): 107842
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.107842
Published online Dec 9, 2025. doi: 10.5409/wjcp.v14.i4.107842
What should be investigated in delayed umbilical cord separation: Two case reports
Dhiaedin A Khiati, Sureyya Savasan, Department of Hematology Oncology, Children's Hospital of Michigan, Detroit, MI 48201, United States
Author contributions: Khiati D conducted data acquisition; Savasan S conceptualized the case report, both authors contributed to writing and reviewing the manuscript. Both authors have read and given approval for the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All Authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE checklist (2016), and the manuscript was prepared and revised according to the CARE checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sureyya Savasan, Professor, Department of Hematology Oncology, Chilrdren's Hospital of Michigan, 3901 Beaubien Blvd., Detroit, MI 48201, United States.
Received: March 30, 2025
Revised: May 11, 2025
Accepted: August 22, 2025
Published online: December 9, 2025
Processing time: 216 Days and 16.7 Hours
Revised: May 11, 2025
Accepted: August 22, 2025
Published online: December 9, 2025
Processing time: 216 Days and 16.7 Hours
Core Tip
Core Tip: Patients with delayed umbilical cord separation (UCS) are often referred to hematology/oncology for investigation of possible Leucocyte adhesion deficiency (LAD) and/or factor XIII deficiency. We highlight the presence of another yet often overlooked association with delayed UCS, urachal remnants and therefore, suggest an abdominal ultrasound if any investigation is sought. Moreover, neither LAD nor factor XIII testing should be conducted routinely at the time of delayed UCS documentation, nor in the long term in cases without infections.