Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Mar 9, 2025; 14(1): 100885
Published online Mar 9, 2025. doi: 10.5409/wjcp.v14.i1.100885
Published online Mar 9, 2025. doi: 10.5409/wjcp.v14.i1.100885
Post-streptococcal acute glomerulonephritis in children: Association between proteinuria levels and renal outcomes
Randula Ranawaka, Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo 0094, Sri Lanka
Randula Ranawaka, Dulani Nelson, University Paediatric Unit, Lady Ridgeway Hospital for Children, Colombo 0094, Western, Sri Lanka
Kavinda Dayasiri, Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Ragama 0094, Sri Lanka
Udara Sandakelum, University Pediatric Unit, Lady Ridgeway Hospital for Children, Colombo 0094, Western, Sri Lanka
Manoji Gamage, Nutrition Division, Ministry of Health, Colombo 0094, Sri Lanka
Author contributions: Ranawaka R was the guarantor and designed the study; Sandakelum U, Nelson D, and Gamage M participated in the acquisition, analysis, and interpretation of the data; Dayasiri K drafted the initial manuscript; Ranawaka R edited the final version of the manuscript; All authors read and approved the final version of the manuscript.
Institutional review board statement: Ethical approval was obtained from Ethical Review Committee, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka (Ref No: LRH/ERC/2021/60).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrolment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Randula Ranawaka, MD, Chief Physician, Professor, Department of Paediatrics, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 0094, Sri Lanka. randula@pdt.cmb.ac.lk
Received: August 30, 2024
Revised: October 22, 2024
Accepted: November 25, 2024
Published online: March 9, 2025
Processing time: 113 Days and 0.3 Hours
Revised: October 22, 2024
Accepted: November 25, 2024
Published online: March 9, 2025
Processing time: 113 Days and 0.3 Hours
Core Tip
Core Tip: This study highlights the significant association between high-grade proteinuria and elevated serum creatinine in children with post-streptococcal acute glomerular nephritis. Children with high-grade proteinuria and elevated serum creatinine require follow-up to monitor long-term kidney function, given the association with the histological presence of crescents and a potential increased risk for chronic kidney disease. Although no association was found between high blood pressure and the degree of proteinuria during the acute phase, further evaluation of this cohort is needed to monitor for late-onset renal hypertension.