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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Sep 9, 2024; 13(3): 95010
Published online Sep 9, 2024. doi: 10.5409/wjcp.v13.i3.95010
Published online Sep 9, 2024. doi: 10.5409/wjcp.v13.i3.95010
Genetic predisposition to childhood cancer
Jelena Roganovic, Department for Pediatric Oncology and Hematology, Children's Hospital Zagreb, Zagreb 10000, Croatia
Jelena Roganovic, Faculty of Biotechnology and Drug Development, University of Rijeka, Rijeka 51000, Croatia
Author contributions: Roganovic J designed and wrote the manuscript.
Conflict-of-interest statement: The author declares no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jelena Roganovic, MD, PhD, Adjunct Professor, Department for Pediatric Oncology and Hematology, Children's Hospital Zagreb, Klaiceva 16, Zagreb 10000, Croatia. jelena.roganovic02@gmail.com
Received: March 30, 2024
Revised: May 7, 2024
Accepted: July 1, 2024
Published online: September 9, 2024
Processing time: 153 Days and 6 Hours
Revised: May 7, 2024
Accepted: July 1, 2024
Published online: September 9, 2024
Processing time: 153 Days and 6 Hours
Core Tip
Core Tip: Genetic predisposition to childhood cancer has gained increasing attention in recent years as a result of our growing knowledge and advancements in molecular biology. It is estimated that at least 10% of children with cancer have an underlying genetic susceptibility to cancer. Identifying germline pathogenic variants in cancer predisposition genes can be of great importance, both for research studies and clinical implications, including preventive measures, a tailored treatment approach to minimize toxicities, comorbidity evaluation, surveillance and follow-up strategies, comprehensive genetic testing and counseling, psychological support of affected children and their families, and ethical considerations.