Published online Nov 9, 2022. doi: 10.5409/wjcp.v11.i6.437
Peer-review started: August 14, 2022
First decision: August 29, 2022
Revised: September 1, 2022
Accepted: October 14, 2022
Article in press: October 14, 2022
Published online: November 9, 2022
Processing time: 84 Days and 10.7 Hours
Milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and disorders. Cow’s milk protein allergy (CMPA) is the most common food allergy, especially in infancy and childhood, which may persist into adulthood. There are three main types of CMPA; immunoglobulin E (IgE)-mediated CMPA, non-IgE-mediated CMPA, and mixed type. CMPA appears before the first birthday in almost all cases. Symptoms may start even during the neonatal period and can be severe enough to simulate neonatal sepsis. CMPA (often non-IgE mediated) can present with symptoms of gastroesophageal reflux, eosinophilic esophagitis, hemorrhagic gastritis, food protein-induced protein-losing enteropathy, and food protein-induced enterocolitis syndrome. Most CMPAs are benign and outgrown during childhood. CMPA is not as common in adults as in children, but when present, it is usually severe with a protracted course. Lactose intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing lactose. Lactose intolerance has four typical types: Developmental, congenital, primary, and secondary. Lactose intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and adults. They are also common in inflammatory bowel diseases. Milk consumption may have preventive or promoter effects on cancer development. Milk may also become a source of microbial infection in humans, causing a wide array of diseases, and may help increase the prevalence of antimicrobial resistance. This editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.
Core Tip: Milk has been a basic human food for hundreds of centuries with a high nutritional value. However, milk can cause various gastrointestinal disorders from early childhood to late adulthood, as many milk ingredients, such as lactose and cow’s milk proteins, can trigger gastrointestinal discomfort and disorders. Cow’s milk protein allergy and lactose intolerance are the most common milk-related disorders. However, milk consumption is related to many functional gastrointestinal disorders, inflammatory bowel disease, milk-related cancer, and milk-born zoonotic infections. Awareness of these disorders is crucial for physicians and patients to avoid unnecessary nutritional mismanagement.