Mavanga NM, Boemer F, Seidel L, Malafu AN, Gothot A, Gerard C. Blood groups, hemoglobin phenotypes and clinical disorders of consanguineous Yansi population. World J Hematol 2013; 2(4): 109-114 [DOI: 10.5315/wjh.v2.i4.109]
Corresponding Author of This Article
Christiane Gerard, PhD, Department of Hematobiology and Immuno-Hematology, CHU-ULg, B35, B-4000 Liege, Belgium. christiane.gerard@chu.ulg.ac.be
Research Domain of This Article
Hematology
Article-Type of This Article
Brief Article
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hematol. Nov 6, 2013; 2(4): 109-114 Published online Nov 6, 2013. doi: 10.5315/wjh.v2.i4.109
Blood groups, hemoglobin phenotypes and clinical disorders of consanguineous Yansi population
Nana Munlemvo Mavanga, François Boemer, Laurence Seidel, André Nkebolo Malafu, André Gothot, Christiane Gerard
Nana Munlemvo Mavanga, André Gothot, Christiane Gerard, Department of Hematobiology and Immuno-Hematology, CHU-ULg, 4000 Liege, Belgium
Nana Munlemvo Mavanga, Centre National de Transfusion Sanguine, Kinshasa, BP 7555 KIN I, Democratic Republic of the Congo
François Boemer, Department of Genetics, CHU-ULg, 4000 Liege, Belgium
Laurence Seidel, Department of Public Health (Biostatistics), CHU-ULg, 4000 Liege, Belgium
André Nkebolo Malafu, Institut Supérieur des Techniques Médicales de Kinshasa (ISTM/KIN), Laboratoire Spécial d’Analyses Biomédicales, Kinshasa, BP 774 KIN XI, Democratic Republic of the Congo
Author contributions: Munlemvo Mavanga N designed the study, collected and analyzed data, drafted the manuscript; Boemer F supervised data collection and revised the manuscript; Seidel L performed statistical analysis of data and contributed to manuscript editing; Nkebolo Malafu A and Gothot A contributed to study conception and revised the manuscript; Gerard C supervised the analysis and interpretation of data and reviewed the manuscript.
Supported by The Belgian Technical Cooperation
Correspondence to: Christiane Gerard, PhD, Department of Hematobiology and Immuno-Hematology, CHU-ULg, B35, B-4000 Liege, Belgium. christiane.gerard@chu.ulg.ac.be
Telephone: +32-4-3667551 Fax: +32-4-3667547
Received: August 6, 2013 Revised: October 8, 2013 Accepted: October 17, 2013 Published online: November 6, 2013 Processing time: 90 Days and 2.6 Hours
Core Tip
Core tip: Assessment of blood group frequencies is important to evaluate the risk of alloimmunization after transfusion or pregnancy. Few documented studies have been published about the frequency of blood groups and extended phenotypes in the Congolese people in general and the consanguineous Yansi tribe in particular. This is also the case for the prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle-cell trait. We show that the distribution of MNS blood groups is different in the Yansi tribe, compared to the general population. The Yansi also present with a higher frequency of medical disorders. This study may help in sensitizing the Congolese population about the medical risks associated with consanguineous unions and in building up a database of genetic diseases in the population.
