Cheng CH, Hao WR, Cheng TH. Multifaceted role of haptoglobin: Implications for disease development. World J Hematol 2024; 11(3): 98807 [DOI: 10.5315/wjh.v11.i3.98807]
Corresponding Author of This Article
Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung 404328, Taiwan. thcheng@mail.cmu.edu.tw
Research Domain of This Article
Hematology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hematol. Sep 19, 2024; 11(3): 98807 Published online Sep 19, 2024. doi: 10.5315/wjh.v11.i3.98807
Multifaceted role of haptoglobin: Implications for disease development
Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng
Chun-Han Cheng, Department of Medical Education, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
Wen-Rui Hao, Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Ministry of Health and Welfare, Taipei Medical University, New Taipei 23561, Taiwan
Wen-Rui Hao, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11002, Taiwan
Tzu-Hurng Cheng, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan
Co-corresponding authors: Wen-Rui Hao and Tzu-Hurng Cheng.
Author contributions: Cheng CH wrote the editorial, including synthesizing recent research findings and developing the manuscript’s key themes; Hao WR and Cheng TH provided critical revisions and guidance throughout the drafting process; all authors have read and approved the final version.
Conflict-of-interest statement: The authors declare that they having have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tzu-Hurng Cheng, PhD, Professor, Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, No. 91 Xueshi Road, North District, Taichung 404328, Taiwan. thcheng@mail.cmu.edu.tw
Received: July 6, 2024 Revised: August 29, 2024 Accepted: September 6, 2024 Published online: September 19, 2024 Processing time: 74 Days and 21.3 Hours
Abstract
Haptoglobin, a protein primarily recognized for its role in sequestering free hemoglobin, has been identified as a molecule with diverse and underexplored functions in the pathophysiology of various diseases. This editorial explores the multifaceted roles of haptoglobin, highlighting its involvement in inflammatory responses and immune regulation and its potential implications in chronic diseases such as diabetes, cardiovascular disorders, and cancer. Through a synthesis of recent research findings, this editorial reveals the importance of haptoglobin in disease mechanisms and underscores the need for further investigation to fully elucidate its therapeutic potential. A comprehensive understanding of haptoglobin’s novel functions may catalyze the development of innovative diagnostic and therapeutic modalities in clinical practice.
Core Tip: This editorial elucidates the under-recognized functions of haptoglobin beyond its established role in hemoglobin sequestration. By highlighting its contributions to inflammatory processes, immune regulation, and the pathogenesis of chronic diseases, this editorial indicates the importance of further research to fully elucidate its therapeutic potential. A comprehensive understanding of haptoglobin’s multifaceted nature may facilitate the development of innovative diagnostic and therapeutic interventions to enhance patient outcomes in various diseases.
